183208-54-0 Usage
Description
1-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine, also known as LSN3213128, is a novel and potent inhibitor of the bromodomain and extraterminal (BET) family of proteins. It is characterized by its ability to selectively target and inhibit BET proteins, which are important epigenetic regulators implicated in various diseases, including cancer and inflammatory disorders. LSN3213128 has demonstrated promising results in preclinical studies, showing its potential as a therapeutic agent for the treatment of these conditions.
Uses
Used in Pharmaceutical Industry:
1-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine is used as a therapeutic agent for the treatment of various diseases, particularly cancer and inflammatory disorders. Its ability to selectively inhibit the BET family of proteins leads to the suppression of tumor growth and inflammation, making it a promising candidate for further research and development in the pharmaceutical industry.
Used in Cancer Treatment:
1-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine is used as an anticancer agent, targeting the BET proteins that play a role in the regulation of gene expression and cell proliferation. By inhibiting these proteins, LSN3213128 can potentially suppress tumor growth and improve outcomes for patients with various types of cancer.
Used in Inflammatory Disorder Treatment:
1-(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine is used as an anti-inflammatory agent, targeting the BET proteins that are involved in the regulation of inflammatory responses. Its ability to inhibit these proteins may help in reducing inflammation and managing inflammatory disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 183208-54-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,3,2,0 and 8 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 183208-54:
(8*1)+(7*8)+(6*3)+(5*2)+(4*0)+(3*8)+(2*5)+(1*4)=130
130 % 10 = 0
So 183208-54-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H12BrN3/c1-14(2)6-7-4-12-10-9(7)3-8(11)5-13-10/h3-5H,6H2,1-2H3,(H,12,13)
183208-54-0Relevant articles and documents
Alkenyl compound and its method and use thereof
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Paragraph 0382; 0393; 0394, (2018/03/01)
The invention provides a new substituted alkenyl compound, pharmaceutically acceptable salts of the new substituted alkenyl compound, a medicinal preparation of the new substituted alkenyl compound, and application of the new substituted alkenyl compound, the pharmaceutically acceptable salts and the medicinal preparation of the new substituted alkenyl compound in aspects of regulating the activity of protein kinase and regulating the intercellular or intracellular signal response. The invention also relates to a medicament composition containing the compound at the same time, and relates to a method for treating high-proliferative diseases of mammals especially the human by using the medicament composition.
Compounds and methods for development of Ret modulators
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Page/Page column 52; 61-62, (2008/06/13)
Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
