18385-72-3

Basic information

• Product Name: 7-Chloro-4-chromanone
• Synonyms: 7-Chloro-4-chromanone;7-Chlorochroman-4-one;7-Chloro-2,3-dihydro-4H-1-benzopyran-4-one;7-Chloro-4-chroManone 97%;7-chloro-2,3-dihydrochroMen-4-one;4H-1-Benzopyran-4-one,7-chloro-2,3-dihydro-
• CAS NO: 18385-72-3
• Molecular Formula: C₉H₇ClO₂
• Molecular Weight: 182.60368
• EINECS: 1312995-182-4
• Mol File: 18385-72-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 65-67℃
• Boiling Point: 322℃
• Flash Point: 150℃
• Appearance: /
• Density: 1.345
• Vapor Pressure: 0.000286mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-Chloro-4-chromanone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-4-chromanone(18385-72-3)
• EPA Substance Registry System: 7-Chloro-4-chromanone(18385-72-3)

Safety Data

• Hazardous Substances Data: 18385-72-3(Hazardous Substances Data)

Usage

General Description

7-Chloro-4-chromanone, also known as 7-chloro-4-oxo-4H-1-benzopyran, is a chemical compound with a molecular formula C9H5ClO2. It is a synthetic intermediate used in the production of pharmaceuticals and agrochemicals. 7-Chloro-4-chromanone is a yellow crystalline solid and is soluble in organic solvents such as ethanol, acetone, and chloroform. It is a versatile building block with potential applications in the development of various drugs and biologically active compounds. 7-Chloro-4-chromanone is also used as a reagent in organic synthesis and chemical research due to its unique structural and functional properties.

InChI:InChI=1/C9H7ClO2/c10-6-1-2-7-8(11)3-4-12-9(7)5-6/h1-2,5H,3-4H2

Upstream product

• 7170-50-5 3-(3-chloro-phenoxy)-propionic acid 
• 126235-12-9 1-(4-Chloro-2-hydroxy-phenyl)-3-dimethylamino-propan-1-one; hydrochloride 
• 6921-66-0 4-chloro-2-hydroxy acetophenone 
• 108-43-0 3-monochlorophenol 
• 106-48-9 4-chloro-phenol 
• 18673-04-6 3-(p-chlorophenoxy)propan-1-ol 
• 3284-79-5 3-(4-chlorophenoxy)propionic acid 
• 18385-81-4 7-chloro chroman-4-ol 

Downstream Products

• 130671-99-7 3-benzylaminomethyl-7-chloro-chroman-4-one 
• 18385-81-4 7-chloro chroman-4-ol 
• 1348827-72-4 1-(7-chloro-2H-chromen-4-yl)methanamine hydrochloride 
• 763907-56-8 7-chlorochroman-4-amine 

Relevant articles and documents

Ionic liquid [bmim]Br assisted chemoselective benzylic [Formula presented] oxidations using tert-butyl hydroperoxide

A mild and efficient, ionic-liquid-assisted green protocol for the chemoselective oxygenation of benzylic C-H bonds to corresponding ketones using ionic liquid [bmim]Br with tert-butyl hydroperoxide has been developed. The method reported in this paper has the advantages of [bmim]Br acting as recyclable solvent and reagent. The usage of additives such as acids or bases and metal salts is not required. The developed strategy is further extended to oxidation of secondary alcohols to respective ketones under similar optimized reaction conditions.

NOVEL ARYL UREA DERIVATIVE

There is a need for FAAH inhibitors capable of oral administration and having excellent efficacy, particularly agents for the prevention and treatment of pain. Disclosed are novel arylurea compounds represented by formula (I), salts or solvates thereof, and pharmaceutical compositions comprising the same as an active ingredient. The pharmaceutical composition is used primarily for FAAH inhibitors, or agents for prevention and treatment of pain.

Chemoenzymatic synthesis and resolution of compounds containing a quaternary stereocenters adjacent to a carbonyl group

Racemic compounds containing a quaternary stereocenter (having hydroxymethyl and alkyl group adjacent to keto functionality) based on chromanone, α-tetralone, and indalone scaffolds have been synthesized. An enzymatic irreversible transesterification approach has been applied to generate the pure enantiomers in a stereocontrolled fashion. The pure enantiomers of some α,α-dialkylated carbonyl compounds have been synthesized by this method.