184643-69-4

Basic information

• Product Name: 1-(4-BROMO-1-METHYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE
• Synonyms: 1-(4-BROMO-1-METHYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE;4-Bromo-1-methyl-2-(trichloroacetyl)-1H-pyrrole
• CAS NO: 184643-69-4
• Molecular Formula: C₇H₅BrCl₃NO
• Molecular Weight: 305.38
• Mol File: 184643-69-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 102-104°C
• Boiling Point: 335.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.79±0.1 g/cm3(Predicted)
• PKA: -12.51±0.70(Predicted)
• CAS DataBase Reference: 1-(4-BROMO-1-METHYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMO-1-METHYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE(184643-69-4)
• EPA Substance Registry System: 1-(4-BROMO-1-METHYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE(184643-69-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 184643-69-4(Hazardous Substances Data)

Usage

Description

1-(4-BROMO-1-METHYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE, commonly known as bromchloron, is a synthetic organic compound characterized by its yellow to brown solid appearance and a strong, unpleasant odor. With the molecular formula C7H6BrCl3NO, this compound is recognized for its effectiveness as a pesticide and herbicide, targeting a broad spectrum of insects and weeds.

Uses

Used in Agricultural Industry:
1-(4-BROMO-1-METHYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE is used as a pesticide for controlling a wide range of insects that can damage crops and reduce agricultural productivity. Its application helps protect plants from harmful pests, ensuring a healthier and more abundant harvest.
1-(4-BROMO-1-METHYL-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE is also used as a herbicide to eliminate unwanted weeds that compete with crops for nutrients, water, and sunlight. By targeting and killing these weeds, bromchloron allows for more efficient use of resources by the desired plant species, leading to improved crop yields.
However, it is crucial to note that bromchloron is highly toxic to aquatic organisms and can persist in the environment. Therefore, its use must be approached with caution to minimize potential harm to human health and the environment. Proper handling, application, and disposal methods are essential to mitigate the risks associated with this chemical.

Upstream product

• 21898-65-7 1-methyl-2-trichloroacetyl-1H-pyrrole 
• 96-54-8 N-Methylpyrrole 

Downstream Products

• 1196-90-3 4-bromo-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 77716-11-1 4-[(tert-butoxycarbonyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid 
• 126092-96-4 methyl 4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrole-2-carboxylate 
• 1146689-63-5 4-bromo-1-methyl-1H-pyrrole-2-carboxylic acid [3-(2-benzenesulfinyl-3-dimethylsulfamoyl-3H-imidazol-4-yl)-propyl]-amide 
• 1187065-42-4 4-(4-aminophenyl)-N-(3-(dimethylamino)propyl)-1-methyl-1H-pyrrole-2-carboxamide 
• 1428305-91-2 4-(4-(3-(2-methylthiazol-4-yl)benzamido)phenyl)-N-(3-(dimethylamino)propyl)-1-methyl-1H-pyrrole-2-carboxamide 
• 864076-02-8 methyl 4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylate 
• 864076-03-9 4-(4-((tert-butoxycarbonyl)amino)phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid 
• 864076-04-0 methyl 4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxylate 
• 1428305-95-6 methyl 4-(4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)phenyl)-1-methyl-1H-pyrrole-2-carboxylate 
• 1428305-99-0 methyl 4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-imidazole-2-carboxylate 
• 1428306-04-0 methyl 4-(4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxylate 
• 1428306-02-8 C₃₀H₃₄N₆O₆ 
• 1428305-84-3 (S)-methyl 4-(4-(4-((7-methoxy-5-oxo-2,3,5,11a-tetrahydro-1Hpyrrolo[2,1-c][1,4]benzodiazepin-8-yl)oxy)butanamido)phenyl)-1-methyl-1H-pyrrole-2-carboxylate 

Relevant articles and documents

Design, Synthesis, and Fungicidal Evaluation of Novel Pyrazole-furan and Pyrazole-pyrrole Carboxamide as Succinate Dehydrogenase Inhibitors

The identification of novel succinate dehydrogenase (SDH) inhibitors represents one of the most attractive directions in the field of fungicide research and development. During our continuous efforts to pursue inhibitors belonging to this class, some structurally novel pyrazole-furan carboxamide and pyrazole-pyrrole carboxamide derivatives have been discovered via the introduction of scaffold hopping and bioisosterism to compound 1, a remarkably potent lead obtained by pharmacophore-based virtual screening. As a result of the evaluation against three destructive fungi, including Sclerotinia sclerotiorum, Rhizoctonia solani, and Pyricularia grisea, a majority of them displayed potent fungicidal activities. In particular, compounds 12I-i, 12III-f, and 12III-o exhibited excellent fungicidal activity against S. sclerotiorum and R. solani comparable to that of commercial SDHI thifluzamide and 1.

GC-Targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models

DNA binding 4-(1-methyl-1H-pyrrol-3-yl)benzenamine (MPB) building blocks have been developed that span two DNA base pairs with a strong preference for GC-rich DNA. They have been conjugated to a pyrrolo[2,1-c][1,4]benzodiazepine (PBD) molecule to produce

PYRROLOBENZODIAZEPINES

Pyrrolobenzodiazepine (PBDs) having a (1-methyl-1H-pyrrol-3- yl)phenyl based amino residue were found to be highly effective compounds having improved cytotoxicity ad DNA binding properties.