184644-72-2 Usage
General Description
Methyl 3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylate is a chemical compound consisting of a methyl ester attached to a thiophene-2-carboxylate group, with a sulfaMoyl substituent attached to the thiophene ring. It also contains a chloro-substituted 3-Methylisoxazol-5-yl group. Methyl 3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylate is commonly used as a synthetic intermediate in the production of pharmaceuticals and agrochemicals, with potential applications in the treatment of various diseases and as a pesticide. However, it is important to handle and use this chemical with care, as it may pose health and environmental risks if not managed properly.
Check Digit Verification of cas no
The CAS Registry Mumber 184644-72-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,4,6,4 and 4 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 184644-72:
(8*1)+(7*8)+(6*4)+(5*6)+(4*4)+(3*4)+(2*7)+(1*2)=162
162 % 10 = 2
So 184644-72-2 is a valid CAS Registry Number.
184644-72-2Relevant articles and documents
SITAXENTAN DERIVATIVE
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Paragraph 0137; 0138; 0139, (2013/08/14)
A compound represented by formula (1-1) or (1-2), or a pharmacologically acceptable salt thereof retains the principal therapeutic effect of sitaxentan and has an improved CYP inhibitory effect: wherein R1 is a halogen atom, etc., R2 is a methyl group, etc., R3 is a C1-6 alkyl group, etc., and M is a group represented by: etc.
Structure-activity relationships of N2-aryl-3-(isoxazolylsulfamoyl)-2- thiophenecarboxamides as selective endothelin receptor-A antagonists
Wu, Chengde,Chan, Ming F.,Stavros, Fiona,Raju,Okun, Ilya,Castillo, Rosario S.
, p. 1682 - 1689 (2007/10/03)
We report here that N2-aryl-3-(isoxazolylsulfamoyl)-2- thiophenecarboxamides are potent and selective small molecule ET(A) receptor antagonists. The aryl group was subjected to extensive structural modification. With monosubstitution, the para