184888-43-5

Basic information

• Product Name: Carbamic acid, [(1R)-1-phenylethyl]-, 1,1-dimethylethyl ester
• CAS NO: 184888-43-5
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.299
• Mol File: 184888-43-5.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1R)-1-phenylethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R)-1-phenylethyl]-, 1,1-dimethylethyl ester(184888-43-5)
• EPA Substance Registry System: Carbamic acid, [(1R)-1-phenylethyl]-, 1,1-dimethylethyl ester(184888-43-5)

Safety Data

• Hazardous Substances Data: 184888-43-5(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 72984-27-1 4-Methyl-N-((R)-1-phenyl-ethyl)-benzenesulfonamide 
• 24865-83-6 4-methyl-N-(1-phenylethylidene)benzenesulfonamide 
• 257298-92-3 (R)-4,4,5,5-tetramethyl-2-(1-phenylethyl)-1,3,2-dioxaborolane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 7782-26-5 (R)-2-Phenylpropionic acid 
• 75-65-0 tert-butyl alcohol 
• 1214919-39-7 C₁₄H₁₉NO₂S 
• 1104640-90-5 t-butyl 3-nitro-1H-1,2,4-triazole-1-carboxylate 
• 73148-41-1 ethyl (Z)-(R)-3-(1-phenyl-ethylamino)but-2-enoate 
• 290357-68-5 ethyl 2-[(1S)-1-(nitromethyl)ethyl]-3-[(1R)-(1-phenylethyl)amino]but-2-enoate 
• 176211-96-4 (4-Methoxy-phenyl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester 

Downstream Products

• 202926-02-1 tert-butyl (R)-pent-4-en-1-yl(1-phenylethyl)carbamate 
• 5933-40-4 (R)-(+)-N,α-dimethylbenzylamine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 173278-27-8 (R)-N-<(tert-butyoxy)carbonyl>-N-methyl-1-phenylethylamine 

Relevant articles and documents

Stereocontrolled substitution of benzylic ethers complexed to tricarbonylchromium(0)

The nitrogen nucleophile HN(OH)C(O)OBu(t) reacts with non-racemic chiral tricarbonylchromium(0) complexes of benzylic ethers with retention of configuration to provide a novel approach to non-racemic N-hydroxycarbamates and amines.

Ultrasound promoted environmentally benign, highly efficient, and chemoselective N-tert-butyloxycarbonylation of amines by reusable sulfated polyborate

The sulfated polyborate catalyzed an efficient and chemoselective N-tert-butyloxycarbonylation of amines under ultrasonic irradiation is developed. A broad substrate scope has been demonstrated for N-Boc protection of various primary/secondary amines. It allows converting several aliphatic/aryl/heteroaryl amines, amino alcohol, aminoester, and chiral amines to their N-Boc-protected derivatives under solvent-free conditions with excellent yields. The protocol has several advantages such as easy catalyst, and product isolation, short reaction time, excellent yields, outstanding chemoselectivity, and catalyst recyclability, among others. This makes the process practicable, economical, and environmentally benign.

Nanoceria as an efficient and green catalyst for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions

Nanocerium oxide mediated an efficient and green protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at ambient temperature. Various aliphatic, aromatic and heteroaromatic amines were protected using developed protocol and several functional groups such as alcohol, phenol and ester were well tolerated under these conditions. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.