185099-67-6

Basic information

• Product Name: N-Boc-Nortropinone
• Synonyms: BOC-NORTROPINONE;BOC-NTP;8-BOC-8-AZABICYCLO[3.2.1]OCTAN-3-ONE;8-AZABICYCLO[3.2.1]OCTAN-3-ONE, N-BOC PROTECTED;N-BOC-NORTROPINONE;TERT-BUTYL 3-OXO-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE;RARECHEM EM WB 0263;N-(tert-Butoxycarbonyl)nortropinone
• CAS NO: 185099-67-6
• Molecular Formula: C₁₂H₁₉NO₃
• Molecular Weight: 225.28
• EINECS: 1592732-453-0
• Product Categories: pharmacetical;Heterocyclic Compounds;Heterocycle;Various Intermediates;Heterocycles;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Fused Ring Systems
• Mol File: 185099-67-6.mol
• Article Data: 59

Chemical Properties

• Melting Point: 70-74 °C
• Boiling Point: 325.8 °C at 760 mmHg
• Flash Point: 150.8 °C
• Appearance: off-white solid
• Density: 1.139 g/cm³
• Vapor Pressure: 0.000225mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: Store at 0-5°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: -1.65±0.20(Predicted)
• CAS DataBase Reference: N-Boc-Nortropinone(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-Nortropinone(185099-67-6)
• EPA Substance Registry System: N-Boc-Nortropinone(185099-67-6)

Safety Data

• Hazard Codes: Xi
• Statements: 41-36/37/38
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 185099-67-6(Hazardous Substances Data)

Usage

Description

N-Boc-Nortropinone, also known as an 8-azabicyclo[3.2.1]octane derivative, is a chemical compound with off-white solid properties. It is characterized by its unique molecular structure and is recognized for its potential as a modulator of opioid receptors.

Uses

Used in Pharmaceutical Industry:
N-Boc-Nortropinone is used as an opioid receptor modulator for its ability to interact with and modulate the activity of opioid receptors in the body. This application is particularly relevant in the development of medications aimed at treating pain and addiction, as well as other conditions that may be influenced by the opioid system.
Used in Research and Development:
In addition to its pharmaceutical applications, N-Boc-Nortropinone is also utilized as a research tool in the field of medicinal chemistry. Its role as an opioid receptor modulator makes it a valuable compound for studying the mechanisms of action, binding properties, and potential therapeutic effects of various opioid-related drugs and treatments.

InChI:InChI=1/C12H19NO3/c1-12(2,3)16-11(15)13-8-4-5-9(13)7-10(14)6-8/h8-9H,4-7H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 5632-84-8 nortropinone 
• 25602-68-0 3-oxo-8-azabicyclo[3.2.1]octane hydrochloride 
• 532-24-1 tropinone 
• 28957-72-4 N-benzyltropinone 
• 50893-53-3 carbonochloridic acid 1-chloro-ethyl ester 
• 5632-84-8 8-azabicyclo[3.2.1]octan-3-one 
• 478837-18-2 3-exo-hydroxy-8-azabicyclo[3.2.1]octane-8carboxylic acid tert-butyl ester 
• 34619-03-9 tert-butyldicarbonate 
• 28957-72-4 N-benzylnortropinone 
• 532-24-1 tropinone 
• 542-05-2 acetonedicarboxylic acid 
• 1185453-81-9 1-(1-(4-methoxyphenyl)pyrrolidin-2-yl)propan-2-one 
• 1159826-74-0 (1R,5S)-8-(tert-butoxycarbonyl)-8-azabicyclo[3.2.1]octane-3-carboxylic acid 

Downstream Products

• 865106-60-1 tert-butyl 3-(2-ethoxy-2-oxoethylidene)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 185099-68-7 tert‐butyl 3‐(trifluoromethanesulfonyloxy)‐8‐azabicyclo[3.2.1]oct‐2‐ene‐8‐carboxylate 
• 617714-57-5 3-(4-Chloro-benzylidene)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester 
• 617714-56-4 3-(3,4-dichloro-benzylidene)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester 
• 863394-54-1 (1R,3R,5S)-3-(3,4-Dichloro-phenyl)-3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester 
• 1245646-51-8 3-trifluoromethanesulfonyloxy-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester 
• 478837-18-2 3-exo-hydroxy-8-azabicyclo[3.2.1]octane-8carboxylic acid tert-butyl ester 
• 953030-71-2 tert-butyl 3-{(3R)-3-[benzyl(cyclopropylcarbonyl)amino]pyrrolidin-1-yl}-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 865106-70-3 3-Cyclopropylmethoxyimino-8-azonia-bicyclo[3.2.1]octane chloride 
• 900503-42-6 3-pyridin-2-yl-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester 
• 900503-45-9 3-benzyl-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester 
• 900503-38-0 3-p-tolyl-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester 
• 900503-37-9 3-(4-methoxyphenyl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester 

Relevant articles and documents

Retro-aza-Michael reaction in continuous flow. Approaches to synthesis of adaline and euphococcinine related products

A retro-aza-Michael ring opening reaction of tropinone and granatanone (pseudopelletierine) in flow setup was investigated and the resulting products were utilized as key intermediates in approaches to adaline and its analogues. The enantioselective flow-reaction gave products of ring opening of granatanone with enantiopurity up to 98% ee. Attempts to elaborate the retro-aza-Michael product to alkaloids are described. Lithiated carbamate derivative of tropane was converted to a tropane analogue of euphococcinine, an adaline related alkaloid (a methyl and tropane homologue of adaline 19). Reactivity of the retro-aza-Michael product under Morita-Baylis-Hillman conditions was also briefly investigated.

METHODS AND COMPOSITIONS FOR MODULATING SPLICING

Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE

The present invention provides novel compounds having the general formula (I) wherein R1 to R6, and m are as described herein, compositions including the compounds and methods of using the compounds.