18515-67-8

Basic information

• Product Name: 3-METHYL-4-NITROBENZALDEHYDE
• Synonyms: 3-METHYL-4-NITROBENZALDEHYDE;3-Methyl-4-nitrobenzaldehyde 98%;5-Formyl-2-nitrotoluene, 4-Formyl-2-methylnitrobenzene;Benzaldehyde, 3-methyl-4-nitro-
• CAS NO: 18515-67-8
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.15
• Mol File: 18515-67-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 304.4 °C at 760 mmHg
• Flash Point: 151.2 °C
• Appearance: /
• Density: 1.278 g/cm³
• Vapor Pressure: 0.000877mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-METHYL-4-NITROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-4-NITROBENZALDEHYDE(18515-67-8)
• EPA Substance Registry System: 3-METHYL-4-NITROBENZALDEHYDE(18515-67-8)

Safety Data

• Hazardous Substances Data: 18515-67-8(Hazardous Substances Data)

Usage

General Description

3-Methyl-4-Nitrobenzaldehyde is a chemical compound with the formula C8H7NO3. This aromatic aldehyde is a derivative of benzaldehyde, that features a nitro and a methyl substituent at the 4 and 3 positions of the benzene ring, respectively. The compound is characterized by a yellow appearance and a strong, sweet odor. As a synthetic intermediate, it has numerous applications in organic syntheses often for preparation of various pharmaceuticals. It can cause eye and skin irritation on contact, highlighting the need for careful handling during use.

InChI:InChI=1/C8H7NO3/c1-6-4-7(5-10)2-3-8(6)9(11)12/h2-5H,1H3

Upstream product

• 89-87-2 2,4-dimethylnitrobenzene 
• 80866-75-7 3-methyl-4-nitrobenzyl alcohol 
• 75-17-2 formaldoxime 
• 7529-22-8 4-methylmorpholine N-oxide 
• 3113-71-1 3-methyl-4-nitrobenzoic acid 

Downstream Products

• 3113-71-1 3-methyl-4-nitrobenzoic acid 
• 80866-75-7 3-methyl-4-nitrobenzyl alcohol 
• 112523-38-3 N,N-Dimethyl-N'-[1-(3-methyl-4-nitro-phenyl)-meth-(E)-ylidene]-benzene-1,4-diamine 
• 36984-54-0 4,4'-Dinitro-3,3'-dimethylbenzoin 
• 570384-35-9 N-[(3-methyl-4-nitro-phenyl)-(toluene-4-sulfonyl)-methyl]-formamide 
• 148582-48-3 2-(2-methyl-4-nitrophenyl)-1,3-dioxolane 
• 1196-69-6 1H-indole-5-carboxaldehyde 
• 1026678-47-6 [(E)-2-(5-[1,3]Dioxolan-2-yl-2-nitro-phenyl)-vinyl]-dimethyl-amine 
• 424834-77-5 4-[Isocyano-(toluene-4-sulfonyl)-methyl]-2-methyl-1-nitro-benzene 
• 424834-29-7 5-[3-(3,4,5-trimethoxy-phenyl)-3H-imidazol-4-yl]-1H-indole 
• 424834-30-0 1-(3,4,5-trimethoxyphenyl)-5-(4-nitro-3-methylphenyl)imidazole 
• 424834-55-9 1-methyl-4-(4-nitro-3-methylphenyl)-5-(3,4,5-trimethoxyphenyl)imidazole 
• 756463-30-6 3-(3-dimethylamino-propyl)-2-(3-methyl-4-nitro-phenyl)-thiazolidin-4-one 
• 18515-14-5 4-(chloromethyl)-2-methyl-1-nitro-benzene 

Relevant articles and documents

A mineralogically-inspired silver–bismuth hybrid material: Structure, stability and application for catalytic benzyl alcohol dehydrogenations under continuous flow conditions

In the present contribution, we are reporting our findings on the structure, stability and synthetic applicability of a silver-containing hybrid material, which has recently been introduced by our research groups as a mineralogically-inspired novel heterogeneous catalyst. To determine how silver ions can be fixed into the structure of the catalyst, a set of experiments was designed with modification of the interlayer gallery under hydrothermal conditions. Subsequently, the stability of the material was examined in various solvents under demanding continuous flow conditions with the aim of achieving a clear picture of its applicability in organic syntheses. On the basis of the useful data obtained during the stability tests, a continuous flow methodology was developed for catalytic dehydrogenation of diversely substituted benzylic alcohols. As far as selectivity is concerned the catalyst performed superbly, while the conversions were varied from fair to extremely good.

Combined production method for substituted benzaldehyde, substituted benzyl alcohol and substituted benzoic acid

The invention discloses a combined production method for substituted benzaldehyde, substituted benzyl alcohol and substituted benzoic acid. The method comprises the following steps: (1) oxidation: a step of continuously introducing substituted toluene, a catalyst and oxygen-contained gas into an oxidation reactor and carrying out reaction so as to obtain oxidation reaction liquid; (2) hydrolyzation: a step of allowing the oxidation reaction liquid to continuously enter a hydrolysis reactor, and continuously adding water into the hydrolysis reactor and carrying out reaction so as to obtain a hydrolysis reaction mixture; (3) liquid-liquid layering: a step of layering the hydrolysis reaction mixture so as to obtain an oil phase and an aqueous phase; and (4) separation of products: a step of subjecting the oil phase to distillation so as to respectively obtain incompletely-reacted substituted toluene, substituted benzyl alcohol and substituted benzaldehyde, and subjecting the aqueous phase to cooling, crystallizing and filtering so as to obtain filtrate and substituted benzoic acid. The combined production method provided by the invention has the advantages of high raw material conversion rate, few by-products, good selectivity of target products, greenness and environmental protection.

KINASE INHIBITORS

The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein variables R, Ar, X, and Ar1 and n are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.