185426-28-2

Basic information

• Product Name: Hexanoic acid, 6-[[2-oxo-2-(phenylmethoxy)ethyl](phenylmethyl)amino]-, 1,1-dimethylethyl ester
• CAS NO: 185426-28-2
• Molecular Formula: C26H35NO4
• Molecular Weight: 425.568
• Mol File: 185426-28-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Hexanoic acid, 6-[[2-oxo-2-(phenylmethoxy)ethyl](phenylmethyl)amino]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hexanoic acid, 6-[[2-oxo-2-(phenylmethoxy)ethyl](phenylmethyl)amino]-, 1,1-dimethylethyl ester(185426-28-2)
• EPA Substance Registry System: Hexanoic acid, 6-[[2-oxo-2-(phenylmethoxy)ethyl](phenylmethyl)amino]-, 1,1-dimethylethyl ester(185426-28-2)

Safety Data

• Hazardous Substances Data: 185426-28-2(Hazardous Substances Data)

Upstream product

• 158141-67-4 tert-butyl 6-(((benzyloxy)carbonyl)amino)hexanoate 
• 5514-98-7 6-aminohexanoic acid tert-butyl ester 
• 1947-00-8 6-(benzyloxycarbonylamino)hexanoic acid 
• 185426-12-4 6-Benzylamino-hexanoic acid tert-butyl ester 
• 5437-45-6 Benzyl bromoacetate 

Relevant articles and documents

Building Units for N-Backbone Cyclic Peptides. 3. Synthesis of Protected Nα-(ω-Aminoalkyl)amino Acids and Nα-(ω-Carboxyalkyl)amino Acids

An improved synthesis of a family of amino acids that contain ω-aminoalkyl groups and of a new family containing ω-carboxyalkyl groups linked to the α-amine is described. The synthesis was performed by alkylation of suitably monoprotected alkylenediamines and protected ω-amino acids with triflates of α-hydroxy acid esters. The reaction proceeded with inversion of configuration yielding optically pure products. The Nα-(ω-aminoalkyl)amino acids and Nα-(ω-carboxyalkyl)amino acids were orthogonally protected to allow their incorporation into peptides by solid-phase peptide synthesis (SPPS) methodology.