185686-48-0

Basic information

• Product Name: {3-[(2E,6E)-2,6-Dimethyl-8-(tetrahydro-pyran-2-yloxy)-octa-2,6-dienyloxymethyl]-phenyl}-phenyl-methanone
• Synonyms: {3-[(2E,6E)-2,6-Dimethyl-8-(tetrahydro-pyran-2-yloxy)-octa-2,6-dienyloxymethyl]-phenyl}-phenyl-methanone
• CAS NO: 185686-48-0
• Molecular Weight: 448.602
• Mol File: 185686-48-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {3-[(2E,6E)-2,6-Dimethyl-8-(tetrahydro-pyran-2-yloxy)-octa-2,6-dienyloxymethyl]-phenyl}-phenyl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: {3-[(2E,6E)-2,6-Dimethyl-8-(tetrahydro-pyran-2-yloxy)-octa-2,6-dienyloxymethyl]-phenyl}-phenyl-methanone(185686-48-0)
• EPA Substance Registry System: {3-[(2E,6E)-2,6-Dimethyl-8-(tetrahydro-pyran-2-yloxy)-octa-2,6-dienyloxymethyl]-phenyl}-phenyl-methanone(185686-48-0)

Safety Data

• Hazardous Substances Data: 185686-48-0(Hazardous Substances Data)

Upstream product

• 106-24-1 Geraniol 
• 59632-99-4 geranyl 2-tetrahydropyranyl ether 
• 110-87-2 3,4-dihydro-2H-pyran 
• 66408-80-8 (2E,6E)-2,6-dimethyl-8-((tetrahydro-2H-pyran-2-yl)oxy)octa-2,6-dien-1-ol 
• 22071-24-5 3-benzoylbenzyl bromide 

Downstream Products

• 185686-52-6 (3-((((2E,6E)-8-bromo-2,6-dimethylocta-2,6-dien-1-yl)oxy)methyl)phenyl)(phenyl)methanone 
• 185686-49-1 (E,E)-8-O-(3-benzoylbenzyl)-3,7-dimethyl-2,6-octadiene-1-ol 

Relevant articles and documents

Farnesyl and geranylgeranyl pyrophosphate analogs incorporating benzoylbenzyl ethers: Synthesis and inhibition of yeast protein farnesyltransferase

The syntheses of two photoactive analogs (1a and 1b) of farnesyl pyrophosphate that incorporate stable ether-linked benzophenones are described. Compounds 1a and 1b were prepared from geraniol in 17% overall yield. Both in and 1b are competitive inhibitors of yeast protein farnesyltransferase with respect to farnesyl pyrophosphate and have K1 values of 45 nM and 49 nM. Upon photolysis for twelve hours, 1a and 1b both inactivate the enzyme by 40%. Copyright (C) 1996 Elsevier Science Ltd.