185854-03-9

Basic information

• Product Name: 6-(benzyloxy)-1,1,1-trifluorohex-3-yn-2-one
• Synonyms: 6-(benzyloxy)-1,1,1-trifluorohex-3-yn-2-one
• CAS NO: 185854-03-9
• Molecular Weight: 256.224
• Mol File: 185854-03-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-(benzyloxy)-1,1,1-trifluorohex-3-yn-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(benzyloxy)-1,1,1-trifluorohex-3-yn-2-one(185854-03-9)
• EPA Substance Registry System: 6-(benzyloxy)-1,1,1-trifluorohex-3-yn-2-one(185854-03-9)

Safety Data

• Hazardous Substances Data: 185854-03-9(Hazardous Substances Data)

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 22273-77-4 ((but-3-yn-1-yloxy)methyl)benzene 
• 100-39-0 benzyl bromide 
• 407-38-5 2,2,2-trifluoroethyl trifluoroacetate 

Relevant articles and documents

Gold-catalyzed synthesis of β-trifluoromethylated α,β-unsaturated ketones from CF3-substituted propargylic carboxylates and their reactivity in Diels-Alder reactions

The synthesis of fluorinated synthetic intermediates has become a field of intense research in organic chemistry. In this article, we report the application of a gold-catalyzed rearrangement to the synthesis of β-trifluoromethylated α,β-unsaturated ketone

Synthesis of a series of trifluoromethylazoles and determination of pKa of acidic and basic trifluoromethyl heterocycles by 19F NMR spectroscopy

Trifluoroacetylation at the 5-position of 3,4-dihydro-2H-pyran and the 3-position of 4,5-dihydrofuran, followed by treatment with hydrazine, gave 3-(3-trifluoromethyl-1H-pyrazol-4-yl)propanol and 2-(3-trifluoromethyl-1H-pyrazol-4-yl)ethanol, respectively.In the latter case, an intermediate dimer was isolated.Isomeric 2-(3-trifluoromethyl-1H-pyrazol-5-yl)ethanol was formed by reaction of hydrazine with 6-benzyloxy-1,1,1-trifluorohex-3-yn-2-one and deprotection.Reaction of 3-benzyloxypropylamine with 2,5-bis(trifluoromethyl)-1,3,4-oxadiazole, followed by deprotection, afforded 3-propanol.A series of 2-trifluoromethyl-1H-benzimidazoles and 2-trifluoromethyl-3H-imidazopyridines were prepared by condensation of the appropriate ortho-arenediamine with trifluoroacetic acid.Analysis of the 19F NMR spectra of the trifluoromethylazoles and of 3-trifluoromethylpyridine in aqueous solution at different pHs enabled determination of pKa values.All the compounds evaluated had one or more pKa between 1 and 13, except the triazole.Several compounds were identified as having potential use in measuring pH in biological media by 19F NMR spectroscopy.