18600-62-9

Basic information

• Product Name: 2-[(2-BROMOBENZOYL)AMINO]BENZOIC ACID
• Synonyms: 2-{[(2-bromophenyl)carbonyl]amino}benzoic acid
• CAS NO: 18600-62-9
• Molecular Formula: C₁₄H₁₀BrNO₃
• Molecular Weight: 320.14
• Mol File: 18600-62-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 397.6 °C at 760 mmHg
• Flash Point: 194.3 °C
• Appearance: /
• Density: 1.624 g/cm³
• Vapor Pressure: 4.9E-07mmHg at 25°C
• CAS DataBase Reference: 2-[(2-BROMOBENZOYL)AMINO]BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-BROMOBENZOYL)AMINO]BENZOIC ACID(18600-62-9)
• EPA Substance Registry System: 2-[(2-BROMOBENZOYL)AMINO]BENZOIC ACID(18600-62-9)

Safety Data

• Hazardous Substances Data: 18600-62-9(Hazardous Substances Data)

Usage

Physical Description

white to off-white powder

Solubility

sparingly soluble in water

Chemical Structure

contains two benzene rings, with a 2-bromobenzoyl and amino functional group attached to one benzene ring, and a carboxylic acid group attached to the other benzene ring

Common Uses

building block in organic synthesis and pharmaceutical research

Potential Applications

development of pharmaceuticals and agrochemicals

InChI:InChI=1/C14H10BrNO3/c15-11-7-3-1-5-9(11)13(17)16-12-8-4-2-6-10(12)14(18)19/h1-8H,(H,16,17)(H,18,19)/p-1

Upstream product

• 18595-86-3 2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one 
• 118-92-3 anthranilic acid 
• 7154-66-7 2-bromobenzoic acid chloride 
• 75541-69-4 2-(2-bromobenzoylamino)benzoic acid methyl ester 
• 88-65-3 2-bromobenzoic-acid 
• 88207-45-8 2-(2'-bromophenyl)-1H-indole 

Downstream Products

• 18595-86-3 2-(2-bromophenyl)-4H-benzo[d][1,3]oxazin-4-one 

Relevant articles and documents

A straightforward TBHP-mediated synthesis of 2-amidobenzoic acids from 2-arylindoles and their antimicrobial activity

A simple and highly efficient strategy has been developed for the synthesis of 2-amidobenzoic acids through the tert-butyl hydroperoxide (TBHP)-mediated oxygenation and sequential ring opening of 2-arylindoles in a one-pot fashion under metal-free aerobic conditions. The developed synthetic protocol is operationally simple, tolerates a wide range of functional groups, and is amenable to the gram-scale. Radical trapping experiments revealed that the reaction involves a radical pathway. The synthesized compounds (2a-s) were tested for in vitro antimicrobial activity. Among all screened compounds, 2d showed the maximum antibacterial activity against P. aerugunosa (ZOI = 17 mm, MIC = 32 μg mL-1) and compounds 2d and 2p showed the maximum (32 μg mL-1) antifungal activity against A. flavus and C. albicans.