18606-63-8

Basic information

• Product Name: N-[4-(dimethylamino)phenyl]formamide
• CAS NO: 18606-63-8
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.2044
• Mol File: 18606-63-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 346.4°C at 760 mmHg
• Flash Point: 163.3°C
• Density: 1.138g/cm³
• Vapor Pressure: 5.79E-05mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: N-[4-(dimethylamino)phenyl]formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(dimethylamino)phenyl]formamide(18606-63-8)
• EPA Substance Registry System: N-[4-(dimethylamino)phenyl]formamide(18606-63-8)

Safety Data

• Hazardous Substances Data: 18606-63-8(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 871876-73-2 2,3-dimethyl-4-nitroso-aniline 
• 64-18-6 formic acid 
• 99-98-9 4-amino-N,N-dimethylaniline 
• 138-89-6 p-dimethylaminonitrosobenzene 
• 298-12-4 Glyoxilic acid 
• 2258-42-6 formyl acetic anhydride 
• 77287-34-4 formamide 

Downstream Products

• 18953-50-9 4-amino-N,N,N-trimethylbenzene ammonium iodide 
• 1202-17-1 (4-dimethylaminophenyl)trimethylammonium iodide 
• 5369-34-6 N,N,N'-trimethyl-p-phenylenediamine 
• 125732-39-0 N,N-dimethyl-4-(1-oxy-benzotriazol-2-yl)-aniline 
• 7050-85-3 4-(dimethylamino)phenyl isocyanide 
• 77486-33-0 N'-(4-Dimethylamino-phenyl)-N,N-dipropyl-formamidine 
• 64-18-6 formic acid 
• 45869-07-6 N¹,N¹-dimethyl-benzene-1,2,4-triyltriamine 
• 2739-06-2 N-(4-(dimethylamino)phenyl)-N-methylformamide 

Relevant articles and documents

Silver-Catalyzed Selective Multicomponent Coupling Reactions of Arynes with Nitriles and Isonitriles

Pathway selective aryne-based novel multicomponent coupling reactions with isonitriles and nitriles are described. Crucial to these reactions is the formation of a silver-aryne complex, which shows differential reactivity toward isonitriles and nitriles to form two different forms of ortho-nitrilium organosilver arene species. Interception of the nitrilium of an aryne-isonitrile adduct with another isonitrile leads to the formation of benzocyclobutene-1,2-diimines, whereas the nitrilium of an aryne-nitrile adduct renders selective formation of 3H-indol-3-imines or 3-iminoindolin-2-ol depending on the structure of the nitrile employed.

A non-catalyst non-promoter under the conditions of amide derivatives of aromatic amine with transfers the amine reaction

The present invention discloses a non-catalyst under the condition of non-accelerator [...] amide derivatives of aromatic amine with transfers the amine reaction, yield of synthetic N - aryl amide derivatives. The method has a wide range of the substrate, its raw materials and cheap and easy to obtain acylation reagent, the reaction yield is high, one-step reaction, low cost, high reaction selectivity, simple operation and the like. Adopting this method can be gram scale can realize the high yield of the synthesis of drug molecules. Therefore, the method in the N - aryl amide derivatives of synthesis application field has very good application prospect. The method overcomes the existing technologies such as the reaction reagent toxicity is large, the need to use different type catalyst, synthesis method and the cost is high, more reaction steps, more byproducts and the like.

Selective Gold-Catalysed Synthesis of Cyanamides and 1-Substituted 1H-Tetrazol-5-Amines from Isocyanides

The newly discovered gold-catalysed reaction of isocyanides with hydrazoic acid generated in situ from trimethylsilyl azide and methanol (or, alternatively, from NaN3/AcOH) produces either cyanamides or 1-substituted 1H-tetrazol-5-amines, depending on the amount of available HN3. The reaction proceeds selectively and in generally high yields of either product, thus providing a particularly convenient access to a wide range of substituted 1H-tetrazol-5-amines that are rather difficult to access otherwise.