186301-25-7Relevant articles and documents
Design, synthesis and anticonvulsant activity of the potent adenosine kinase inhibitor GP3269
Erion, Mark D.,Ugarkar, Bheemarao G.,DaRe, Jay,Castellino, Angelo J.,Fujitaki, James M.,Dixon, Ross,Appleman, James R.,Wiesner, James B.
, p. 1013 - 1021 (1997)
The pyrrolopyrimidine nucleoside GP3269 (12) was shown to be a potent and selective inhibitor of human adenosine kinase (IC50 = 11 nM) and to exhibit anticonvulsant activity in rats after oral administration. Synthesis of GP3269 was accomplishe