186377-56-0 Usage
Description
BrinzolaMide IMpurity C, also known as O-Desmethyl Brinzolamide, is a derivative of Brinzolamide (B677601), which is a carbonic anhydrase inhibitor. It is primarily used in the pharmaceutical industry for the treatment of intraocular pressure in patients.
Uses
Used in Pharmaceutical Industry:
BrinzolaMide IMpurity C is used as an ocular topical treatment for patients experiencing intraocular pressure. It functions as a carbonic anhydrase inhibitor, reducing the rate of aqueous humor formation, which in turn decreases intraocular pressure. This makes it a valuable compound in the development of treatments for glaucoma and other eye conditions related to high intraocular pressure.
Check Digit Verification of cas no
The CAS Registry Mumber 186377-56-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,6,3,7 and 7 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 186377-56:
(8*1)+(7*8)+(6*6)+(5*3)+(4*7)+(3*7)+(2*5)+(1*6)=180
180 % 10 = 0
So 186377-56-0 is a valid CAS Registry Number.
186377-56-0Relevant articles and documents
Design, synthesis, and evaluation of no-donor containing carbonic anhydrase inhibitors to lower intraocular pressure
Huang, Qinhua,Rui, Eugene Y.,Cobbs, Morena,Dinh, Dac M.,Gukasyan, Hovhannes J.,Lafontaine, Jennifer A.,Mehta, Saurabh,Patterson, Brian D.,Rewolinski, David A.,Richardson, Paul F.,Edwards, Martin P.
, p. 2821 - 2833 (2015/04/14)
The antiglaucoma drugs dorzolamide (1) and brinzolamide (2) lower intraocular pressure (IOP) by inhibiting the carbonic anhydrase (CA) enzyme to reduce aqueous humor production. The introduction of a nitric oxide (NO) donor into the alkyl side chain of do
