186537-56-4Relevant articles and documents
Total synthesis of (2RS)-α-tocopherol through Ni-catalyzed 1,4-addition to a chromenone intermediate
Termath, Andreas Ole,Velder, Janna,Stemmler, Rene T.,Netscher, Thomas,Bonrath, Werner,Schmalz, Hans-Guenther
, p. 3337 - 3340 (2014)
A novel strategy for the total synthesis of α-tocopherol ("vitamin E") was elaborated on the basis of the conjugate addition of AlMe3 (as a methyl anion equivalent) to a 2-substituted chromenone. Starting from trimethylhydroquinone and (R,R)-he
Oxalate as an activated ester group in lipase-catalyzed enantioselective hydrolysis: A versatile approach to d-α-tocopherol
Mizuguchi,Achiwa
, p. 2303 - 2306 (1993)
The d-α-tocopherol was synthesized effectively by enzyme-catalyzed enantioselective hydrolysis of dl-α-tocopherol oxalate. The enzymes can recognize a stereogenic carbon atom remote from the reaction site.
Process of separating chiral isomers of chroman compounds and their derivatives and precursors
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Page/Page column 15, (2012/12/13)
The present invention relates to a process of separating chiral isomers of chroman compounds, particularly tocopherols and tocotrienols as well as the esters and intermediates thereof. It has been found that this process allows a separation of the desired isomer with a higher yield and enables the use of the non-desired isomers in a very efficient way. Said process is particularly useful when implemented in an industrial process. Furthermore, it has been found that this process allows using isomer mixtures as they result from traditional industrial synthesis.