18718-83-7

Basic information

• Product Name: Isoxazole, 4-(chloromethyl)-5-methyl-3-phenyl-
• CAS NO: 18718-83-7
• Molecular Formula: C11H10ClNO
• Molecular Weight: 207.659
• Mol File: 18718-83-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Isoxazole, 4-(chloromethyl)-5-methyl-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazole, 4-(chloromethyl)-5-methyl-3-phenyl-(18718-83-7)
• EPA Substance Registry System: Isoxazole, 4-(chloromethyl)-5-methyl-3-phenyl-(18718-83-7)

Safety Data

• Hazardous Substances Data: 18718-83-7(Hazardous Substances Data)

Upstream product

• 2065-28-3 methyl 5-methyl-3-phenylisoxazole-4-carboxylate 
• 18718-79-1 5-methyl-3-phenyl-4-isoxazolylmethanol 

Downstream Products

• 154265-46-0 2-<(5'-methyl-3'-phenylisoxazol-4'-yl)ethyl>-4,4-dimethyl-Δ²-oxazoline 
• 1239465-23-6 6-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-nicotinic acid 
• 1254969-88-4 4-methyl-2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid 
• 1254969-89-5 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid 
• 1254968-46-1 rac-4-methyl-2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid (2-hydroxy-1-methyl-ethyl)-amide 
• 1254968-44-9 4-methyl-2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid iso-propylamide 
• 1254968-49-4 4-methyl-2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid amide 
• 1159601-05-4 (5-Methyl-3-phenyl-isoxazol-4-ylmethyl)-pyridin-2-yl-amine 
• 99298-87-0 C₃₇H₃₄N₄O₄ 
• 154265-47-1 ethyl 3-<5'-methyl-3'-phenylisoxazol-4'-yl>propanoate 
• 99298-80-3 C₂₁H₂₃N₃O₃ 
• 18718-89-3 1-(5-methyl-3-phenyl-isoxazol-4-ylmethyl)-piperidine 

Relevant articles and documents

Design, synthesis and biological evaluation of stilbene derivatives as novel inhibitors of protein tyrosine phosphatase 1B

By imitating the scaffold of lithocholic acid (LCA), a natural steroidal compound displaying Protein Tyrosine Phosphatase 1B (PTP1B) inhibitory activity, a series of stilbene derivatives containing phenyl-substituted isoxazoles were designed and synthesized. The structures of the title compounds were confirmed by 1H-NMR, 13C-NMR and HRMS. Activities of the title compounds were evaluated on PTP1B and the homologous enzyme TCPTP by using a colorimetric assay. Most of the target compounds had good activities against PTP1B. Among them, compound 29 (IC50 = 0.91 ± 0.33 μM), characterized by a 5-(2,3-dichlorophenyl) isoxazole moiety, exhibited an activity about 14-fold higher than the lead compound LCA and a 4.2-fold selectivity over TCPTP. Compound 29 was identified as a competitive inhibitor of PTP1B with a Ki value of 0.78 μM in enzyme kinetic studies.