187344-92-9Relevant articles and documents
Synthesis of novel C2 and C1 symmetric chiraphos derivatives and their application in palladium-catalyzed miyauramichael reaction
Jin, Masayoshi,Nakamura, Masaharu
, p. 1035 - 1037 (2013)
A new method for the synthesis of C2 and C1 symmetric CHIRAPHOS derivatives and their application in Pd-catalyzed 1,4-addition reaction of an aryl boron compound to an ,¢-unsaturated carbonyl compound (MiyauraMichael reaction) are described. Six CHIRAPHOS congeners are prepared by substitution reactions of (2R,3R)-butane-2,3-diyl ditosylate with metalated phosphineborane adducts and subsequent deprotection of the resulting borane-protected bisphosphines. In the asymmetric MiyauraMichael reaction, the CHIRAPHOS derivative containing 4-tolyl groups showed a higher enantioselectivity than the others including parent CHIRAPHOS.
Highly Enantioselective Synthesis of Phosphorus-Containing ?-Benzosultams by Bifunctional Phosphonium Salt-Promoted Hydrophosphonylation
Zhang, Song,Feng, Zhenghuai,Jiang, Chunhui,Yu, Xiaojun,Pan, Jianke,Du, Juan,Jiang, Zhiyu,Chen, Yuan,Wang, Tianli
supporting information, p. 11285 - 11290 (2021/07/02)
?-Benzosultam derivatives are potential drug candidates with diverse biological activities. A series of chiral ?-benzosultams bearing phosphorus functionalities was synthesized by catalytic asymmetric hydrophosphonylation in the presence of a bifunctional phosphonium salt catalyst. The desired hydrophosphonylation products were obtained in good yields with high enantioselectivities, and scale-up reactions and further derivations were successfully accomplished. Some control experiments were also conducted to elucidate the plausible reaction mechanism of this chemical transformation.
Cinchona alkali ligand and preparation method and application thereof
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Paragraph 0085-0088; 0093-0096; 0128-0129; 0134-0135; ..., (2021/12/31)
The invention belongs to the field of organic chemical ligands, and particularly relates to a cinchona alkali ligand, which has a structure shown in a general formula I or a tautomer, an enantiomer and a diastereoisomer thereof, in the formula I, R1 is selected from alkyl, alkenyl and -CH = CHPh, R2 is selected from hydrogen, alkyl, phenyl and substituted phenyl, and R is selected from substituted phenyl. The invention also discloses a preparation method and application of the cinchona alkaloid ligand. The ligand disclosed by the invention has advantages in stereoselectivity and reaction efficiency, and a higher ee value and yield can be obtained in an asymmetric reaction.