1874-23-3 Usage
Description
Methyl 5-nitro-2-furoate is a nitrofuran derivative characterized by its yellowish crystalline powder form. It has been evaluated for its density, freezing point, and refractive index. METHYL 5-NITRO-2-FUROATE can be reduced using milk xanthine oxidase to form methyl 5-hydroxylamino-2-furoate and methyl 5-amino-2-furoate. Additionally, its utility as a matrix compound for matrix-assisted ionization vacuum (MAIV) has been assessed with bovine insulin as an analyte.
Uses
Used in Chemical Synthesis:
Methyl 5-nitro-2-furoate is used as a chemical intermediate for the synthesis of 5-nitro-2-furoylhydrazine and 5-nitro-2-furamide. These synthesized compounds can have various applications in different industries, depending on their properties and reactivity.
Used in Analytical Chemistry:
In the field of analytical chemistry, methyl 5-nitro-2-furoate serves as a matrix compound for matrix-assisted ionization vacuum (MAIV) techniques. This application aids in the analysis of complex samples, such as proteins like bovine insulin, by enhancing ionization efficiency and improving detection capabilities.
Check Digit Verification of cas no
The CAS Registry Mumber 1874-23-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,7 and 4 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1874-23:
(6*1)+(5*8)+(4*7)+(3*4)+(2*2)+(1*3)=93
93 % 10 = 3
So 1874-23-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H5NO5/c1-11-6(8)4-2-3-5(12-4)7(9)10/h2-3H,1H3
1874-23-3Relevant articles and documents
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Freure,Johnson
, p. 1142 (1931)
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A New Process for the Total Synthesis of Sparstolonin B
Tang, Xiaohang,Tong, Le,Yao, Mengyi,Liang, Qiaoli,Wang, Xiaolong,Yu, Haitao
, p. 1187 - 1190 (2017/06/13)
A novel and simple route was developed that gives sparstolonin B in high yields from affordable commercial compounds. A Diels-Alder strategy was used for the facile construction of the multisubstituted diphenyl ether. The xanthenone segment was obtained by cyclization in an intramolecular Friedel-Crafts reaction, followed by selective reduction of a ketone group and a transformation from a hydroxy group into a cyano group. The final part of the lactone was directly derived by the reduction of the cyano group with Raney nickel.
Continuous flow oxidation of alcohols and aldehydes utilizing bleach and catalytic tetrabutylammonium bromide
Leduc, Andrew B.,Jamison, Timothy F.
supporting information; experimental part, p. 1082 - 1089 (2012/08/27)
We report a method for the oxidation of a range of alcohols and aldehydes utilizing a simple flow system of alcohols in EtOAc with a stream of 12.5% NaOCl and catalytic Bu4NBr. Secondary alcohols are oxidized to ketones, aldehydes are oxidized directly to methyl esters in the presence of methanol, and benzylic alcohols are oxidized to either benzaldehydes or methyl esters, depending on the conditions used. The reaction conditions are mild and generally provide complete conversion in 5-30 min.
