18781-80-1

Basic information

• Product Name: 2H-Pyran-2-one, 3-acetyl-5,6-dihydro-4-hydroxy-6-methyl-
• CAS NO: 18781-80-1
• Molecular Formula: C8H10O4
• Mol File: 18781-80-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2H-Pyran-2-one, 3-acetyl-5,6-dihydro-4-hydroxy-6-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran-2-one, 3-acetyl-5,6-dihydro-4-hydroxy-6-methyl-(18781-80-1)
• EPA Substance Registry System: 2H-Pyran-2-one, 3-acetyl-5,6-dihydro-4-hydroxy-6-methyl-(18781-80-1)

Safety Data

• Hazardous Substances Data: 18781-80-1(Hazardous Substances Data)

Upstream product

• 85825-79-2 6-methyltetrahydropyran-2,4-dione 
• 64-19-7 acetic acid 
• 771-03-9 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one 
• 108-24-7 acetic anhydride 
• 79039-98-8 6-Methyl-4-pyrrolidino-5,6-dihydro-2-pyranone 
• 7272-81-3 methyl-6 dihydro-5,6 morpholino-4 pyrone-2 
• 33177-29-6 5,6-dihydro-4-hydroxy-6-methyl-2H-pyran-2-one 
• 75-36-5 acetyl chloride 
• 520-45-6 Dehydracetic acid 

Relevant articles and documents

Evaluation of heteroatom-rich derivatives as antitubercular agents with InhA inhibition properties

Two series of heterocyclic compounds derived from 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one (DHA) and 2-acetylbutyrolactone have been synthesized and characterized. The compounds were evaluated for their activities against Mycobacterium tuberculosis stra

Total synthesis and stereochemistry of alternaric acid

Determination of the stereochemistry and the total synthesis of alternaric acid 1 has been achieved. The stereostructure of 1 has been elucidated by stereoselective synthesis of four diastereoisomers of the C(9)-C(14) fragment 6, which had been obtained as a degradation product during structural studies. Key reactions of the total synthesis of 1 include the Julia olefination of tertiary aldehyde 6 and phenylsulfone 7 and novel one-pot construction of 3-acyl-4-hydroxy-5,6-dihydro-2-pyrone via Fries-type rearrangement of the O-enol acyl group of β-keto-δ-valerolactone toward the α-position of the δ-lactone. The absolute configuration of alternaric acid has been shown to be that illustrated in structure 1. The modified Fries-type rearrangement method has also been extended to the synthesis of some other compounds containing a tricarbonylmethane structure.

Structure et syntheses nouvelles dans la serie des amino-4-dihydro-5,6- methyl-6 pyrones-2

Primary and secondary amines react with 4-hydroxy-5,6-dihydro-2-pyrones at position 4, and not at position 2 as previously indicated.However, a new series of compounds is obtained by this reaction, some of them exhibiting therapeutic properties.Reactiviti