18797-79-0 Usage
Description
Corynoline, a benzophenanthridine alkaloid with the empirical formula C21H21NO5, is derived from the aerial parts of Corydalis incisa. It is characterized by its substitution of a methyl group at position 13 on chelidonine. Corynoline exhibits a range of pharmacological activities, including cell adhesion inhibition, sedation, liver protection, acetylcholinesterase inhibition, antineoplastic effects, and hepatoprotective properties.
Uses
Used in Pharmaceutical Applications:
Corynoline is used as a therapeutic agent for its various pharmacological activities. It is particularly valuable for its ability to inhibit cell adhesion, which can be beneficial in treating conditions where cell adhesion is a contributing factor.
Used in Sedative Applications:
Due to its sedative properties, Corynoline can be used as a calming agent in the treatment of anxiety, stress, and sleep disorders.
Used in Liver Protection:
Corynoline's hepatoprotective activity makes it a potential candidate for use in the development of treatments for liver diseases and conditions where liver function is compromised.
Used in Antineoplastic Applications:
Corynoline's antineoplastic properties suggest its potential use in the development of cancer treatments, particularly for inhibiting the growth and spread of cancer cells.
Used in Acetylcholinesterase Inhibition:
As an acetylcholinesterase inhibitor, Corynoline can be utilized in the development of treatments for neurological disorders, such as Alzheimer's disease, where the inhibition of acetylcholinesterase is a key therapeutic approach.
Check Digit Verification of cas no
The CAS Registry Mumber 18797-79-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,7,9 and 7 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 18797-79:
(7*1)+(6*8)+(5*7)+(4*9)+(3*7)+(2*7)+(1*9)=170
170 % 10 = 0
So 18797-79-0 is a valid CAS Registry Number.
InChI:InChI=1/C21H21NO5/c1-21-14-3-4-15-19(27-10-24-15)13(14)8-22(2)20(21)12-7-17-16(25-9-26-17)5-11(12)6-18(21)23/h3-5,7,18,20,23H,6,8-10H2,1-2H3/t18-,20+,21-/m0/s1
18797-79-0Relevant articles and documents
A BIOMIMETIC SYNTHESIS OF -CORYNOLINE, -11-EPICORYNOLINE, -ISOCORYNOLINE, AND -EPIISOCORYNOLINE FROM CORYSAMINE
Hanaoka, Miyoji,Yoshida, Shuji,Mukai, Chisato
, p. 6621 - 6624 (2007/10/02)
A novel and efficient synthesis of hexahydrobenzophenanthridine alkaloids, -corynoline, -11-epicorynoline, -isocorynoline, and -11-epiisocorynoline was accomplished from protoberberine alkaloid, corysamine through a biogenetic route.
Studies on the alkaloids of the papaveraceae. XVII. The alkaloids of Corydalis incisa. X. The structure of (+) 14 epicorynolin
Takao,Bersch,Takao
, p. 1096 - 1102 (2007/10/07)
-
