1881-37-4 Usage
Description
4-fluoroestradiol is a synthetic derivative of the hormone estradiol, modified with the addition of a fluorine atom. It possesses high affinity for estrogen receptors and has been studied for its potential applications in hormone replacement therapy and as a radioligand for imaging estrogen receptor-positive tumors.
Uses
Used in Hormone Replacement Therapy:
4-fluoroestradiol is used as a hormone replacement agent for addressing hormone-dependent conditions, such as menopausal symptoms. Its high affinity for estrogen receptors makes it a promising candidate for this application.
Used in Cancer Therapy and Diagnostic Imaging:
4-fluoroestradiol is used as a targeted cancer therapy agent for estrogen receptor-positive tumors. Its high affinity for estrogen receptors allows for selective targeting of cancer cells, making it a potential candidate for both therapeutic intervention and diagnostic imaging.
Used in Pharmaceutical Industry:
4-fluoroestradiol is used as a radioligand in the pharmaceutical industry for the development of drugs targeting estrogen receptor-positive tumors. Its unique properties make it a valuable tool in the discovery and optimization of new therapeutic agents.
However, further research is needed to determine the safety and efficacy of 4-fluoroestradiol for these uses.
Check Digit Verification of cas no
The CAS Registry Mumber 1881-37-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,8 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1881-37:
(6*1)+(5*8)+(4*8)+(3*1)+(2*3)+(1*7)=94
94 % 10 = 4
So 1881-37-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H23FO2/c1-18-9-8-11-10-4-6-15(20)17(19)13(10)3-2-12(11)14(18)5-7-16(18)21/h4,6,11-12,14,16,20-21H,2-3,5,7-9H2,1H3
1881-37-4Relevant articles and documents
Fluorination of steroid estrogens with Selectfluor??: Elucidation of regio- and stereoselectivity
Bogautdinov, Roman P.,Fidarov, Alan F.,Morozkina, Svetlana N.,Zolotarev, Andrei A.,Starova, Galina L.,Selivanov, Stanislav I.,Shavva, Alexander G.
, p. 218 - 222 (2015/03/05)
Two steroid estrogens, natural estradiol and 8?±-estradiol, were fluorinated using Selectfluor?? in ionic liquid. Unexpectedly, mostly products of fluorination at position C-10 were isolated instead of corresponding fluorophenols, as it was reported previ
Direct Fluorination of Biologically Interesting Compounds Using N-Fluoro-3,5-Dichloropyridinium Triflate
Hebel, David,Kirk, Kenneth L.
, p. 179 - 183 (2007/10/02)
N-fluoro-3,5-dichloropyridinium triflate was used for the direct fluorination of biologically important aromatic compounds.
Fluorination of Activated Aromatic Systems with Cesium Fluoroxysulfate
Patrick, Timothy B.,Darling, Diana L.
, p. 3242 - 3244 (2007/10/02)
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