188181-17-1

Basic information

• Product Name: 2-(4-Iodo-phenyl)-3-oxo-3,5-dihydro-2H-pyridazino[4,3-b]indole-4-carboxylic acid
• CAS NO: 188181-17-1
• Molecular Weight: 431.189
• Mol File: 188181-17-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-Iodo-phenyl)-3-oxo-3,5-dihydro-2H-pyridazino[4,3-b]indole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Iodo-phenyl)-3-oxo-3,5-dihydro-2H-pyridazino[4,3-b]indole-4-carboxylic acid(188181-17-1)
• EPA Substance Registry System: 2-(4-Iodo-phenyl)-3-oxo-3,5-dihydro-2H-pyridazino[4,3-b]indole-4-carboxylic acid(188181-17-1)

Safety Data

• Hazardous Substances Data: 188181-17-1(Hazardous Substances Data)

Upstream product

• 14370-76-4 diethyl 2-(3-oxo-2,3-dihydro-1H-2-indolyliden)malonate 
• 91-56-5 indole-2,3-dione 
• 612-54-4 2-chloro-3H-indol-3-one 
• 188180-99-6 2-(4-Iodo-phenyl)-3-oxo-3,5-dihydro-2H-pyridazino[4,3-b]indole-4-carboxylic acid ethyl ester 
• 13116-27-3 4-iodophenylhydrazine 

Relevant articles and documents

Structure-activity relationships of 2-Aryl-2,5-dihydropyridazino [4,3-b]indol-3(3H)-ones at the benzodiazepine receptor

A large series of 2-aryl-2,5-dihydropyridazino[4,3-b]indol-3(3H)ones (PIs) carrying properly selected substituents at the indole and N2-phenyl rings was prepared and tested as central benzodiazepine receptor (BZR) ligands and potential (anti)convulsant agents. Stereoelectronic requirements for high receptor affinity were detected by means of 2-D and 3-D QSAR analyses. BZR affinities and pharmacological profiles of the compounds were examined in comparison with some other pyridazinoindolones recently described by us and with pyrazoloquinoline (PQ) analogues. An anticonvulsant activity greater than PQs was generally observed for PIs. Notably, in the test of audiogenically induced seizures, one compound showed a potency comparable to that of diazepam.