1882-82-2Relevant articles and documents
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Halpern,Djerassi
, p. 439 (1959)
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Meister et al.
, p. 416 (1953)
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Methylprednisolone intermediate debrominated product and preparation method thereof
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, (2020/02/10)
The invention discloses a methylprednisolone intermediate debrominated product and a preparation method thereof. According to the preparation method, a compound shown as a formula I is used as a raw material, and a dechlorination reaction, a bromination reaction, a debromination reaction and an oxidation reaction are sequentially performed to prepare a compound (debrominated substance) shown as aformula V. The preparation method has the advantages of short synthetic route, high yield, low cost and easily available raw materials, is suitable for industrial production, and has very high industrial value.
Multi-hydroxy pregnane 11 α hydroxy selective oxidation method
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Paragraph 0008; 0019; 0020, (2017/02/17)
The invention provides a selective oxidation method for selective oxidation method for polyhydroxy-pregna-11alpha-hydroxy. According to the invention, pregna-4-ene-3,20-diketone-11alpha,17alpha-dihydroxy is used as a substrate and reacts with dimethyl sulfoxide and an activator in liquid chloroalkane, and alkali is added after completion of the reaction so as to adjust a pH value to 8.5 to 10, thereby obtaining pregna-4-ene-3,11,20-triketone-17alpha-hydroxy.