188400-92-2

Basic information

• Product Name: 1H-Imidazole, 1-(4-hydrazinophenyl)-
• CAS NO: 188400-92-2
• Molecular Formula: C9H10N4
• Molecular Weight: 174.205
• Mol File: 188400-92-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole, 1-(4-hydrazinophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole, 1-(4-hydrazinophenyl)-(188400-92-2)
• EPA Substance Registry System: 1H-Imidazole, 1-(4-hydrazinophenyl)-(188400-92-2)

Safety Data

• Hazardous Substances Data: 188400-92-2(Hazardous Substances Data)

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 2301-25-9 1-(4-nitrophenyl)-1H-imidazole 
• 2221-00-3 4-(N-imidazolyl)aniline 

Relevant articles and documents

HYDRAZONE DERIVATIVE

A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof

3-[3-(piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists

Several 5-HT(ID/1B) receptor agonists are now entering the marketplace as treatments for migraine. This paper describes the development of selective h5-HT(1D)receptor agonists as potential antimigraine agents which may produce fewer side effects. A series of 3-[3-(piperidin-1-yl)propyl]indoles has been synthesized which has led to the identification of 80 (L-772,405), a high- affinity h5-HT(1D) receptor full agonist having 170-fold selectivity for h5- HT(1D) receptors over h5-HT(1B) receptors. L-772,405 also shows very good selectivity over a range of other serotonin and nonserotonin receptors and has excellent bioavailability following subcutaneous administration in rats. It therefore constitutes a valuable tool to delineate the role of h5-HT(1D) receptors in migraine. Molecular modeling and physical properties have been utilized to postulate the binding conformation of these compounds in the receptor cavity.