188416-38-8

Basic information

• Product Name: (2R,3S)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1 yl)butan-2-ol
• Synonyms: (2R,3S)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1 yl)butan-2-ol
• CAS NO: 188416-38-8
• Molecular Weight: 383.76
• Mol File: 188416-38-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,3S)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1 yl)butan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1 yl)butan-2-ol(188416-38-8)
• EPA Substance Registry System: (2R,3S)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1 yl)butan-2-ol(188416-38-8)

Safety Data

• Hazardous Substances Data: 188416-38-8(Hazardous Substances Data)

Upstream product

• 1403893-61-7 4-chloro-5-fluoro-6-vinylpyrimidine 
• 86404-63-9 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone 

Downstream Products

• 137234-62-9 voriconazole 

Relevant articles and documents

Method for synthesizing voriconazole

The invention provides a method for synthesizing voriconazole, belonging to the field of medicine synthesis. The method comprises the following steps: by taking an intermediate A as a raw material, performing catalytic reaction with potassium formate and palladium-charcoal in the presence of inert gas so as to obtain a crude product of voriconazole, and recrystallizing the crude product of voriconazole, thereby obtaining voriconazole. According to the method, potassium formate is adopted as a hydrogen source and palladium-charcoal is adopted as a catalyst, helium atoms on pyrimidine rings of the intermediate A are removed, and thus raceme of voriconazole can be obtained. According to the method, the quantity of byproducts is few, the product quality is high, the reaction condition is gentle, the process security is high and the method is applicable to industrial large-scale production.