188616-79-7Relevant articles and documents
A Short Synthesis of the Factor-Xa Inhibitor DX-9065a Using Palladium-Catalyzed Key Steps1
Kehr, Christiane,Neidlein, Richard,Engh, Richard A.,Brandstetter, Hans,Kucznierz, Ralf,Leinert, Herbert,Marzenell, Klaus,Strein, Klaus,Von Der Saal, Wolfgang
, p. 892 - 896 (1997)
We describe a new, efficient synthesis of DX-9065a (4), a potent inhibitor of the blood coagulation enzyme factor Xa (fXa) which has previously been prepared in more than 20 steps. We saved approximately 10 steps starting with a Pd-catalyzed cyanation of
Process for preparing 2-phenyl-3-naphthylpropionic acid derivatives
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, (2008/06/13)
A process for preparing a compound represented by general formulae (5) and (6) in the following reaction scheme or salts thereof, wherein R1represents a protective group for a nitrogen atom; R2represents a methanesulfonyl group or p-