1889-59-4 Usage
Description
Ethyl vinyl sulfone is a clear yellow liquid that is known for its ability to alkylate ε-amino groups of lysine side chains and imidazole groups of histidine residues in proteins. This chemical modification has been studied through X-ray photoelectron spectroscopy, particularly in the context of bovine serum albumin.
Uses
Used in Pharmaceutical Industry:
Ethyl vinyl sulfone is used as a chemical modifier for proteins, such as bovine serum albumin, to study the effects of alkylation on ε-amino groups of lysine side chains and imidazole groups of histidine residues. This application is crucial for understanding protein structure and function, as well as for developing new therapeutic agents and drug delivery systems.
Used in Chemical Research:
Ethyl vinyl sulfone serves as a valuable tool in chemical research, particularly in the study of protein-protein interactions, enzyme mechanisms, and the development of novel chemical probes. Its ability to alkylate specific amino acid residues allows researchers to investigate the role of these residues in various biological processes and to design targeted protein modifications.
Used in Bioconjugation:
Ethyl vinyl sulfone is used as a bioconjugation agent to attach proteins, peptides, or other biomolecules to various surfaces or carriers. This application is important in the development of biosensors, drug delivery systems, and other biocompatible materials that require the covalent attachment of biologically active molecules.
Used in Analytical Chemistry:
Ethyl vinyl sulfone can be employed as a derivatization agent in analytical chemistry to modify and analyze complex protein mixtures or to improve the detection and quantification of specific amino acid residues in proteomic studies. Its reactivity with ε-amino groups and imidazole groups allows for selective and efficient labeling of proteins for mass spectrometry or other analytical techniques.
Check Digit Verification of cas no
The CAS Registry Mumber 1889-59-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,8 and 9 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1889-59:
(6*1)+(5*8)+(4*8)+(3*9)+(2*5)+(1*9)=124
124 % 10 = 4
So 1889-59-4 is a valid CAS Registry Number.
InChI:InChI=1/C4H8O2S/c1-3-7(5,6)4-2/h3H,1,4H2,2H3
1889-59-4Relevant articles and documents
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Sayigh,A.A.R. et al.
, p. 2042 - 2043 (1964)
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Mo(VI) complex catalysed synthesis of sulfonees and their modification for anti-HIV activities
Madduluri, Vimal Kumar,Baig, Noorullah,Chander, Subhash,Murugesan, Sankaranarayanan,Sah, Ajay K.
, (2020/01/23)
An efficient method for the synthesis of sulfones has been developed using sugar derived cis-dioxo molybdenum(VI) complex as catalyst and urea hydrogen peroxide as oxygen source. Present method is highly specific for sulfide oxidation irrespective of presence of alkene and aldehyde groups in the same molecule. Synthesis of fifteen sulfones have been reported with 82–98% isolated yields and the catalyst has been reused five times without any loss in its activity. 2-(Phenylsulfonyl)aniline has been condensed with eight different aromatic aldehydes and the products are being explored for HIV-1 reverse transcriptase inhibition activities.
Difluoro- and trifluoro diazoalkanes-complementary approaches in batch and flow and their application in cycloaddition reactions
Hock, Katharina J.,Mertens, Lucas,Metze, Friederike K.,Schmittmann, Clemens,Koenigs, Rene M.
supporting information, p. 905 - 909 (2017/08/14)
Herein we report on applications of fluorinated diazoalkanes in cycloaddition reactions, with the emphasis on studying subtle differences between diverse fluorinated diazo compounds. These differences led to two major synthetic protocols in batch and flow that allow the safe and scalable synthesis of fluoroalkyl-, sulfone-substituted pyrazolines.
