188943-06-8

Basic information

• Product Name: 2'-methyl-, methyl ester
• Synonyms: 2'-methyl-, methyl ester
• CAS NO: 188943-06-8
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226.27046
• Mol File: 188943-06-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2'-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-methyl-, methyl ester(188943-06-8)
• EPA Substance Registry System: 2'-methyl-, methyl ester(188943-06-8)

Safety Data

• Hazardous Substances Data: 188943-06-8(Hazardous Substances Data)

Usage

Description

2'-methyl-, methyl ester, also known as Methyl 2''-Methyl-[1,1''-biphenyl]-2-carboxylate, is an organic compound that serves as a reagent in the synthesis of nonpeptide arginine vasopressin antagonists for both V1A and V2 receptors.

Uses

Used in Pharmaceutical Industry:
2'-methyl-, methyl ester is used as a reagent for the synthesis of nonpeptide arginine vasopressin antagonists for both V1A and V2 receptors. These antagonists have potential applications in the treatment of various medical conditions, such as diabetes insipidus, heart failure, and certain types of hypertension. The synthesis of these antagonists using 2'-methyl-, methyl ester allows for the development of more effective and targeted therapies.

Upstream product

• 16419-60-6 2-Methylphenylboronic acid 
• 342-54-1 2-(methoxycarbonyl)benzenediazonium tetrafluoroborate 
• 95-46-5 2-methylphenyl bromide 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 51471-72-8 (2-methoxycarbonyl-phenylsulfanyl)-acetic acid 
• 7029-31-4 bis(2-methylphenyl)zinc 
• 13029-09-9 2,2'-dibromobiphenyl 
• 79-22-1 methyl chloroformate 
• 74-88-4 methyl iodide 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 88-65-3 2-bromobenzoic-acid 
• 66107-34-4 2-methylphenyl triflate 
• 51207-44-4 methyl 2-{[(4-methylphenyl)sulfonyl]oxy}benzoate 

Downstream Products

• 7111-77-5 2'-methyl[1,1'-biphenyl]-carboxylic acid 
• 158443-23-3 tricarbonylchrominum(methyl 2'-methyl-1,1'-biphenyl-2-carboxylate) 
• 73527-16-9 bis(tricarbonylchrominum)(methyl 2'-methyl-1,1'-biphenyl-2-carboxylate) 
• 1859-10-5 4-methylfluoren-9-ol 
• 7111-68-4 2'-methylbiphenyl-2-carboxaldehyde 
• 484-17-3 9-Phenanthrol 
• 60848-13-7 N-methylphenanthren-9-amine 

Relevant articles and documents

Visible-Light-Induced Arene C(sp 2)-H Lactonization Promoted by DDQ and tert -Butyl Nitrite

A visible-light photocatalytic aerobic oxidative lactonization of arene C(sp 2)-H bonds proceeds in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and tert -butyl nitrite (TBN). Under the optimized conditions, a range of 2-arylbenzoic acids is converted into the corresponding benzocoumarin derivatives in moderate to excellent yields. This method is characterized by its atom economy, mild reaction conditions, the use of a green oxidant and metal-free catalysis.

Exploration of Biaryl Carboxylic Acids as Proton Shuttles for the Selective Functionalization of Indole C-H Bonds

A survey of diversely substituted 2-arylbenzoic acids were synthesized and tested for use as proton shuttle in the direct arylation of indoles with bromobenzenes. It was found that 3-ethoxy-2-phenylbenzoic acid gives superior yield and selectivity for this class of substrates.

Synthesis of fluorenones through rhodium-catalyzed intramolecular acylation of biarylcarboxylic acids

An efficient approach to the synthesis of fluorenones via the rhodium-catalyzed intramolecular acylation of biarylcarboxylic acids was developed. Using this procedure, fluorenones with various substituents can be synthesized in good to high yields. This work marks the first recorded use of catalytic intramolecular acylation to synthesize fluorenones.