18922-72-0

Basic information

• Product Name: 2-(4-NITROPHENYL)-2H-1,2,3-TRIAZOLE
• Synonyms: 2-(4-NITROPHENYL)-2H-1,2,3-TRIAZOLE
• CAS NO: 18922-72-0
• Molecular Formula: C₈H₆N₄O₂
• Molecular Weight: 190.1588
• Mol File: 18922-72-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 380.7°Cat760mmHg
• Flash Point: 184°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 5.35E-06mmHg at 25°C
• Refractive Index: 1.696
• CAS DataBase Reference: 2-(4-NITROPHENYL)-2H-1,2,3-TRIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-NITROPHENYL)-2H-1,2,3-TRIAZOLE(18922-72-0)
• EPA Substance Registry System: 2-(4-NITROPHENYL)-2H-1,2,3-TRIAZOLE(18922-72-0)

Safety Data

• Hazardous Substances Data: 18922-72-0(Hazardous Substances Data)

Usage

General Description

2-(4-Nitrophenyl)-2H-1,2,3-triazole is a chemical compound with the molecular formula C9H6N4O2. It is a triazole derivative with a nitrophenyl group attached to the triazole ring. 2-(4-NITROPHENYL)-2H-1,2,3-TRIAZOLE is often used in organic synthesis and as a building block for the preparation of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including antimicrobial, antitumor, and anti-inflammatory properties. The nitro group in 2-(4-nitrophenyl)-2H-1,2,3-triazole gives it a characteristic yellow color, and it is important to handle this compound with caution due to its potential toxicity.

InChI:InChI=1/C8H6N4O2/c13-12(14)8-3-1-7(2-4-8)11-9-5-6-10-11/h1-6H

Upstream product

• 51039-49-7 2-phenyl-2H-[1,2,3]triazole 
• 288-36-8 1,2,3-triazole 
• 350-46-9 4-Fluoronitrobenzene 
• 288-36-8 1 ,2,3-Triazole 
• 1534-21-0 glyoxal bis(phenylhydrazone) 
• 67-64-1 acetone 

Downstream Products

• 52708-34-6 4-(1H-1,2,3-triazol-2-yl)benzenamine 
• 181870-10-0 1-[4-(2H-1,2,3-triazol-2-yl)phenyl]-2(1H,3H)-imidazolone 
• 181869-84-1 C₉H₁₀N₆O 
• 181869-76-1 (4-[1,2,3]triazol-2-yl-phenyl)-carbamic acid phenyl ester 
• 181870-04-2 1-(2,2-diethoxy-ethyl)-3-(4-[1,2,3]triazol-2-yl-phenyl)-urea 
• 181869-25-0 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2H-1,2,3-triazol-2-yl)phenyl]-2(1H,3H)-imidazolone 
• 855934-92-8 N-acetyl-sulfanilic acid-(4-[1,2,3]triazol-2-yl-anilide) 

Relevant articles and documents

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

NOVEL COMPOUNDS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

HIV PROTEASE INHIBITORS

Compounds of Formula I are disclosed: wherein A, R1, R2, R3, R4A, R4B, R5, R6 and R7 are defined herein. The compounds encompassed by Formula I include compounds which