189340-39-4Relevant articles and documents
In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors
Lu, Tianbao,Tomczuk, Bruce,Illig, Carl R.,Bone, Roger,Murphy, Larry,Spurlino, John,Salemme, F. Raymond,Soll, Richard M.
, p. 1595 - 1600 (2007/10/03)
We describe the in vitro evaluation and crystallographic analysis of a new class of potent and selective, non-aminoacid-based, small-molecule thrombin inhibitors, exemplified by 14. This class of achiral inhibitors lacks an amide-based backbone, exhibits nM inhibition of thrombin, and is selective for thrombin. Compound 14 does not interact with the active-site catalytic apparatus and is anchored to the enzyme via a single network of hydrogen bonds to Asp 189 of the S1 pocket.
