18944-28-0 Usage
Description
3-KETO-DIHYDROSPHINGOSINE HCL, also known as 3-Ketodihydrosphingosine, is a bioactive compound derived from N-Boc-L-Serine, which is an N-Boc-protected form of L-Serine. L-Serine is a non-essential amino acid that plays a crucial role in the synthesis of sphingolipids and phosphatidylserine, compounds that are vital for central nervous system neuronal survival. Additionally, L-Serine is significant in intermediary metabolism in eukaryotic cells.
Uses
Used in Pharmaceutical Industry:
3-KETO-DIHYDROSPHINGOSINE HCL is used as an intermediate compound for the synthesis of various pharmaceuticals targeting central nervous system disorders. Its role in the synthesis of sphingolipids and phosphatidylserine makes it a valuable component in the development of drugs aimed at improving neuronal survival and function.
Used in Biochemical Research:
In the field of biochemical research, 3-KETO-DIHYDROSPHINGOSINE HCL serves as an essential research tool for studying the metabolic pathways and functions of L-Serine, sphingolipids, and phosphatidylserine. This understanding can lead to the development of novel therapeutic strategies for various neurological and metabolic disorders.
Used in Nutraceutical Industry:
3-KETO-DIHYDROSPHINGOSINE HCL can be utilized as an active ingredient in the development of nutraceutical products designed to support cognitive health and neuronal function. Its involvement in the synthesis of essential compounds for the central nervous system makes it a promising candidate for enhancing brain health and overall well-being.
Check Digit Verification of cas no
The CAS Registry Mumber 18944-28-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,9,4 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18944-28:
(7*1)+(6*8)+(5*9)+(4*4)+(3*4)+(2*2)+(1*8)=140
140 % 10 = 0
So 18944-28-0 is a valid CAS Registry Number.
18944-28-0Relevant articles and documents
Simplifungin and Valsafungins, Antifungal Antibiotics of Fungal Origin
Ishijima, Hiroyuki,Uchida, Ryuji,Ohtawa, Masaki,Kondo, Ariko,Nagai, Kenichiro,Shima, Keisuke,Nonaka, Kenichi,Masuma, Rokuro,Iwamoto, Susumu,Onodera, Hideyuki,Nagamitsu, Tohru,Tomoda, Hiroshi
, p. 7373 - 7383 (2016)
The targets of antifungal antibiotics in clinical use are more limited than those of antibacterial antibiotics. Therefore, new antifungal antibiotics with different mechanisms of action are desired. In the course of our screening for antifungal antibiotics of microbial origins, new antifungal antibiotics, simplifungin (1) and valsafungins A (2) and B (3), were isolated from cultures of the fungal strains Simplicillium minatense FKI-4981 and Valsaceae sp. FKH-53, respectively. The structures of 1 to 3 including their absolute stereochemistries were elucidated using various spectral analyses including NMR and collision-induced dissociation (CID)-MS/MS as well as chemical approaches including modifications to the Mosher's method. They were structurally related to myriocin. They inhibited the growth of yeast-like and zygomycetous fungi with MICs ranging between 0.125 and 8.0 μg/mL. An examination of their mechanisms of action by the newly established assay using LC-MS revealed that 1 and 2 inhibited serine palmitoyltransferase activity, which is involved in sphingolipid biosynthesis, with IC50 values of 224 and 24 nM, respectively.