189453-27-8

Basic information

• Product Name: Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-(tert-butyl-dimethyl-silanyloxy)-13,13-dimethoxy-4,8,10,12,12-pentamethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-11-triphenylsilanyloxy-tridec-3-enyl ester
• Synonyms: Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-(tert-butyl-dimethyl-silanyloxy)-13,13-dimethoxy-4,8,10,12,12-pentamethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-11-triphenylsilanyloxy-tridec-3-enyl ester
• CAS NO: 189453-27-8
• Molecular Weight: 912.434
• Mol File: 189453-27-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-(tert-butyl-dimethyl-silanyloxy)-13,13-dimethoxy-4,8,10,12,12-pentamethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-11-triphenylsilanyloxy-tridec-3-enyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-(tert-butyl-dimethyl-silanyloxy)-13,13-dimethoxy-4,8,10,12,12-pentamethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-11-triphenylsilanyloxy-tridec-3-enyl ester(189453-27-8)
• EPA Substance Registry System: Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-(tert-butyl-dimethyl-silanyloxy)-13,13-dimethoxy-4,8,10,12,12-pentamethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-11-triphenylsilanyloxy-tridec-3-enyl ester(189453-27-8)

Safety Data

• Hazardous Substances Data: 189453-27-8(Hazardous Substances Data)

Upstream product

• 189453-18-7 (1E,3S,5Z)-6-iodo-2-methyl-1-(2-methyl-1,3-thiazol-4-yl)-1,5-heptadien-3-yl acetate 
• 184246-38-6 (E)-2-methyl-3-(2-methylthiazol-4-yl)acrylaldehyde 
• 197233-11-7 [(4R,5R,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-yloxy]-triphenyl-silane 
• 197233-09-3 (3R,4R,5S,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-3-iodomethyl-2-methoxy-3,5-dimethyl-tetrahydro-pyran-4-ol 
• 197233-10-6 (4R,5S,6S)-6-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methoxy-3,3,5-trimethyl-tetrahydro-pyran-4-ol 
• 197233-25-3 Acetic acid (E)-(S)-2-methyl-3-(2-methyl-thiazol-4-yl)-1-(2-oxo-ethyl)-allyl ester 
• 188259-62-3 (1S)-[(1E)-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethynyl]-3-butenyl acetate 
• 187283-46-1 (S,E)-2-methyl-1-(2-methylthiazol-4-yl)hexa-1,5-dien-3-ol 
• 184297-50-5 (1R,3S,4S,5R,6R)-3-((S)-2-Benzyloxy-1-methyl-ethyl)-4,6-dimethyl-2-oxa-bicyclo[4.1.0]heptan-5-ol 
• 184297-49-2 (2S,3R)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-3,5-dimethyl-2,3-dihydro-pyran-4-one 
• 184478-38-4 (2S,3S,4R)-2-((S)-2-Benzyloxy-1-methyl-ethyl)-3,5-dimethyl-3,4-dihydro-2H-pyran-4-ol 
• 186692-59-1 2-[(2R,3R,4S,5S)-6-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-hexyl]-[1,3]dithiane 
• 186692-61-5 2-[(E)-(2R,3R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-7-methoxy-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-hept-6-enyl]-[1,3]dithiane 
• 186692-75-1 (3S,4S,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-[1,3]dithian-2-yl-3,5,7-trimethyl-6-triphenylsilanyloxy-octanal 

Downstream Products

• 189453-30-3 Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-(tert-butyl-dimethyl-silanyloxy)-4,8,10,12,12-pentamethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-13-oxo-11-triphenylsilanyloxy-tridec-3-enyl ester 
• 152044-54-7 epothilone B 
• 189453-35-8 (4S,7R,8S,9S,13Z,16S,1'E)-4,8-di-tert-butyldimethylsilyloxy-5,5,7,9,13-pentamethyl-16-[1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-ethenyl]-1-oxa-13-cyclohexadecene-2,6-dione 
• 189453-32-5 (Z)-(6R,7R,8S,9S,16S)-8-(tert-Butyl-dimethyl-silanyloxy)-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-6-triphenylsilanyloxy-oxacyclohexadec-13-ene-2,4-dione 
• 189453-47-2 (Z)-(4R,6R,7R,8S,9S,16S)-8-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-6-triphenylsilanyloxy-oxacyclohexadec-13-en-2-one 
• 189453-43-8 (Z)-(4S,6R,7R,8S,9S,16S)-8-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-6-triphenylsilanyloxy-oxacyclohexadec-13-en-2-one 
• 189453-10-9 epothilone D 

Relevant articles and documents

Synthesis of epothilones, intermediates thereto, analogues and uses thereof

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

Total Synthesis of ( - )-Epothlone B: An Extension of the Suzuki Coupling Method and Insights into Structure - Activity Relationships of the Epothilones

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