1899-99-6

Basic information

• Product Name: 2-Chloro-4-methoxy-6-methyl-5-nitropyrimidine
• Synonyms: 2-Chloro-4-methoxy-6-methyl-5-nitropyrimidine
• CAS NO: 1899-99-6
• Molecular Formula: C₆H₆ClN₃O₃
• Molecular Weight: 203.584
• Mol File: 1899-99-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 371.366 °C at 760 mmHg
• Flash Point: 178.396 °C
• Appearance: /
• Density: 1.455 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Chloro-4-methoxy-6-methyl-5-nitropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-methoxy-6-methyl-5-nitropyrimidine(1899-99-6)
• EPA Substance Registry System: 2-Chloro-4-methoxy-6-methyl-5-nitropyrimidine(1899-99-6)

Safety Data

• Hazardous Substances Data: 1899-99-6(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-methoxy-6-methyl-5-nitropyrimidine is a chemical compound belonging to the pyrimidine class. It is a nitro-substituted derivative with a chloro, methoxy, and methyl groups attached to the pyrimidine ring. 2-Chloro-4-methoxy-6-methyl-5-nitropyrimidine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has several industrial applications, including its use as a building block for the manufacturing of various pesticides and pharmaceutical products. Due to its versatile chemical properties and wide range of applications, 2-Chloro-4-methoxy-6-methyl-5-nitropyrimidine is a valuable compound in organic chemistry.

InChI:InChI=1/C6H6ClN3O3/c1-3-4(10(11)12)5(13-2)9-6(7)8-3/h1-2H3

Upstream product

• 13162-26-0 2,4-dichloro-6-methyl-5-nitropyrimidine 
• 124-41-4 sodium methylate 
• 16632-21-6 6-methyl-5-nitropyrimidine-2,4-diol 
• 626-48-2 2,4-dihydroxy-6-methylpyrimidine 

Downstream Products

• 1067228-97-0 4-methoxy-6-methyl-5-nitro-2-(2,4,6-trimethyl-phenyl)-pyrimidine 
• 1067228-96-9 2-(2,6-dimethoxy-phenyl)-4-methoxy-6-methyl-5-nitro-pyrimidine 
• 1067228-95-8 2-(2,4-dimethoxy-phenyl)-4-methoxy-6-methyl-5-nitro-pyrimidine 
• 1067228-94-7 2-(2,4-dichloro-phenyl)-4-methoxy-6-methyl-5-nitro-pyrimidine 
• 360576-58-5 3-methoxy-2-(4-methoxy-6-methyl-5-nitropyrimidin-2-yl)-1,5-dimethylbenzene 
• 1067229-00-8 2-(2,4-dichloro-phenyl)-4-methoxy-6-methyl-pyrimidin-5-ylamine 
• 1067229-01-9 4-methoxy-6-methyl-2-(2,4,6-trimethyl-phenyl)-pyrimidin-5-ylamine 
• 360576-93-8 2-(2,6-dimethoxy-phenyl)-4-methoxy-6-methyl-pyrimidin-5-ylamine 
• 391936-67-7 2-(2,4-dimethoxy-phenyl)-4-methoxy-6-methyl-pyrimidin-5-ylamine 
• 360576-59-6 4-methoxy-2-(2-methoxy-4,6-dimethyl-phenyl)-6-methyl-pyrimidin-5-ylamine 
• 600178-93-6 2-(2,6-dimethoxy-phenyl)-5-dipropylamino-6-methyl-3H-pyrimidin-4-one 
• 360577-05-5 [2-(2,4,6-trimethylphenyl)-4-methoxy-6-methyl pyrimidin-5-yl]dipropylamine 
• 360577-01-1 [2-(2,4-dichlorophenyl)-4-methoxy-6-methylpyrimidin-5-yl]dipropylamine 
• 391936-52-0 2-(2,4-dimethoxy-phenyl)-5-dipropylamino-6-methyl-3H-pyrimidin-4-one 

Relevant articles and documents

Synthetic Strategies toward the Synthesis of 2,4-Dimethoxypyrrolopyrimidine

Two approaches to prepare 2,4-dimethoxypyrrolopyrimidine (1) are described. 2,4-Dimethoxy-6-methyl-5-nitropyrimidine (2) was converted to 6-(cyanomethyl)-2,4-dimethoxy-5-nitropyrimidine (6) in two steps.Subsequent catalytic hydrogenation of 6 produced 1.In a second approach, 2 was formylated, giving rise to 6--2,4-dimethoxy-5-nitropyrimidine (7).Hydrogenation of 7 resulted in the formation of 1.Reduction of 2 provided 5-amino-2,4-dimethoxy-6-methylpyrimidine (10).Reaction of compound 10 with triethyl orthoformate produced 2,4-dimethoxy-5--6-methylpyrimidine (11).Reaction of 11 with lithium diisopropylamide gave 2,4-dimethoxy-5-isocyano-6-methylpyrimidine (12).

2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel CRF-1 receptor antagonists

The discovery, synthesis and structure-activity studies of a novel series of 2-arylpyrimidin-4-ones as CRF-1 receptor antagonists is described. These compounds are structurally simple and display appropriate physical properties for CNS agents