19006-63-4

Basic information

• Product Name: 1-PROPYL-2(1H)-PYRIDINONE
• Synonyms: 1-PROPYL-2(1H)-PYRIDINONE;TIMTEC-BB SBB008029;1-Propyl-2(1H)-pyridone;1-Propyl-2-pyridone;2(1H)-Pyridinone, 1-propyl-;2(1H)-Pyridone, 1-propyl-;N-n-Propyl-2-pyridone;1-Propyl-1,2-dihydropyridine-2-one
• CAS NO: 19006-63-4
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.18
• Mol File: 19006-63-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 282 °C at 760 mmHg
• Flash Point: 131.1 °C
• Appearance: /
• Density: 1.018 g/cm³
• Vapor Pressure: 0.00345mmHg at 25°C
• Refractive Index: 1.504
• CAS DataBase Reference: 1-PROPYL-2(1H)-PYRIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PROPYL-2(1H)-PYRIDINONE(19006-63-4)
• EPA Substance Registry System: 1-PROPYL-2(1H)-PYRIDINONE(19006-63-4)

Safety Data

• Hazardous Substances Data: 19006-63-4(Hazardous Substances Data)

Usage

General Description

1-PROPYL-2(1H)-PYRIDINONE is a chemical compound with the molecular formula C8H9NO. It is a pyridine derivative and is used primarily as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a solvent for various purposes, including in the production of paints, coatings, and adhesives. It is known for its mild odor and is a colorless liquid at room temperature. Additionally, 1-PROPYL-2(1H)-PYRIDINONE is considered to be relatively stable and is compatible with a wide range of other chemicals. It is important to handle this compound with care, as it may cause irritation upon contact with the skin or eyes.

InChI:InChI=1/C8H11NO/c1-2-6-9-7-4-3-5-8(9)10/h3-5,7H,2,6H2,1H3

Upstream product

• 21997-30-8 1-(prop-2-enyl)-1,2-dihydropyridine-2-one 
• 3902-84-9 potassium 2-oxo-2H-pyridin-1-ide 
• 107-08-4 1-iodo-propane 
• 142-08-5 2-hydroxypyridin 
• 106-94-5 propyl bromide 
• 142-08-5 2-Pyridone 
• 109-04-6 2-bromo-pyridine 
• 1628-89-3 2-methoxypyridine 
• 101870-22-8 2-propoxypyridine 
• 110-86-1 pyridine 
• 39868-02-5 1-propylpyridin-1-ium iodide 

Downstream Products

• 19006-74-7 1-n-Propyl-pyridthion-(2) 
• 126707-83-3 2-Propyl-2-aza-bicyclo[2.2.0]hex-5-en-3-one 
• 126707-82-2 1-Propyl-4-<1-(diethylamino)ethyl>-3,4-dihydropyridin-2(1H)-one 
• 873396-19-1 1-propyl-piperidine-2-thione 

Relevant articles and documents

Iron-catalyzed regioselective direct arylation at the C-3 position of N-alkyl-2-pyridone

A number of pharmaceutical compounds possess an arylated 2-pyridone moiety. The existing reports using expensive starting materials and/or superstoichiometric metal salts have prompted us to explore a possible user-friendly method for their synthesis. In this report, we demonstrate an easy-to-handle reaction condition with an iron catalyst for the exclusive generation of C-3-arylated pyridone via C-H functionalization.

Homosecoiridoid alkaloids with amino acid units from the flower buds of lonicera japonica

Nine new homosecoiridoid alkaloids, named lonijaposides O-W (1-9), along with 19 known compounds, were isolated from an aqueous extract of the flower buds of Lonicera japonica. Their structures and absolute configurations were determined by spectroscopic data analysis and chemical methods. Lonijaposides O-W have structural features that involve amino acid units sharing the N atom with a pyridinium (1-5) or nicotinic acid (6-9) moiety. The absolute configurations of the amino acid units were determined by oxidation of each pyridinium ring moiety with potassium ferricyanide, hydrolysis of the oxidation product, and Marfey's analysis of the hydrolysate. This procedure was validated by oxidizing and hydrolyzing synthetic model compounds. The phenylalanine units in compounds 4, 5, and 9 have the d-configuration, and the other amino acid units in 1-3 and 6-8 possess the l-configuration. Compounds 1, 4, 6, and 9 and the known compounds 3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, and 5′-O-methyladenosine exhibited antiviral activity against the influenza virus A/Hanfang/359/95 (H3N2) with IC50 values of 3.4-11.6 μM, and 4 inhibited Coxsackie virus B3 replication with an IC50 value of 12.3 μM.

Value of zeolites in asymmetric induction during photocyclization of pyridones, cyclohexadienones and naphthalenones

Two strategies, namely chiral inductor and chiral auxiliary approaches, have been examined within zeolites with the aim of achieving asymmetric induction during the photocyclization of cyclohexadienone, naphthalenone and pyridone derivatives. Within zeoli