190846-24-3

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 2-[2-[(methylsulfonyl)oxy]ethyl]-, phenylmethyl ester
• Synonyms: N-Benzyloxycarbonyl-2(S)-(2-methanesulphonyloxyethyl)piperidine;N-benzyloxycarbonyl-2(RS)-(2-methanesulfonyloxyethyl)piperidine;2-(2-Methanesulfonyloxy-ethyl)-piperidine-1-carboxylic acid benzyl ester
• CAS NO: 190846-24-3
• Molecular Formula: C16H23NO5S
• Molecular Weight: 341.42300
• Mol File: 190846-24-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 509.9±33.0 °C(Predicted)
• Density: 1.231±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 2-[2-[(methylsulfonyl)oxy]ethyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 2-[2-[(methylsulfonyl)oxy]ethyl]-, phenylmethyl ester(190846-24-3)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 2-[2-[(methylsulfonyl)oxy]ethyl]-, phenylmethyl ester(190846-24-3)

Safety Data

• Hazardous Substances Data: 190846-24-3(Hazardous Substances Data)

Upstream product

• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 
• 124-63-0 methanesulfonyl chloride 
• 39945-50-1 2-(2-hydroxyethyl)-piperidine-1-carboxylic acid benzyl ester 

Downstream Products

• 441771-91-1 N-[N-(α-fluorenylmethoxycarbonyl)-(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine 
• 441772-01-6 N-(N-cyclohexyl-N-ethyl-O-t-butyl-(S)-α-aspartyl)-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine 
• 441771-97-7 N-[N-(2,2,2-trichloroethoxycarbonyl)-(R)-cyclohexylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine 
• 190846-63-0 N-(N-cyclohexyl-N-ethyl-O-t-butyl-(S)-α-aspartyl)-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine 
• 441771-99-9 N-[N-(t-butoxycarbonylmethyl)-(R)-cyclohexylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine 
• 190846-53-8 N-(N-cyclohexylmethyl-O-t-butyl-(S)-α-aspartyl)-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine 
• 190846-42-5 N-(N-cyclohexyl-O-t-butyl-(S)-α-aspartyl)-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine 
• 441771-93-3 N-[N-(t-butoxycarbonylmethyl)-(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine 
• 441771-98-8 N-[(R)-cyclohexylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine 
• 441771-95-5 N-[N-(2,2,2-trichloroethoxycarbonyl)-(R)-cyclohexylalanyl]-2(RS)-[2-(N-t-butoxycarbonyl-4-piperidinyloxy)ethyl]piperidine 
• 441771-92-2 N-[(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine 
• 190846-26-5 N-benzyloxycarbonyl-2(RS)-[2-(N-t-butoxycarbonyl-4-piperidyloxy)ethyl]piperidine 

Relevant articles and documents

2-substituted piperidines that are ligands for monoamine receptors and transporters

One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.