191168-66-8

Basic information

• Product Name: Butanamide, 4-chloro-N-(4-methylphenyl)-
• CAS NO: 191168-66-8
• Molecular Formula: C11H14ClNO
• Molecular Weight: 211.691
• Mol File: 191168-66-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Butanamide, 4-chloro-N-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, 4-chloro-N-(4-methylphenyl)-(191168-66-8)
• EPA Substance Registry System: Butanamide, 4-chloro-N-(4-methylphenyl)-(191168-66-8)

Safety Data

• Hazardous Substances Data: 191168-66-8(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 96-48-0 4-butanolide 
• 99-99-0 1-methyl-4-nitrobenzene 

Downstream Products

• 3063-79-4 N-(4-methylphenyl)-2-pyrrolidinone 
• 1159836-44-8 N-(4-methylphenyl)tetramethylenediamine 
• 1286232-06-1 4-azido-N-(4-methylphenyl)butyramide 
• 919111-30-1 3-(p-tolylcarbamoyl)propyltriphenylphosphonium chloride 
• 191168-87-3 4-Piperazin-1-yl-N-p-tolyl-butyramide 
• 186667-93-6 diethyl [1-(4-methylphenyl)pyrrolidin-2-ylidene]malonate 
• 58973-35-6 N-(4-methylphenyl)pyrrolidine-2-thione 
• 191168-75-9 4-(4-Benzyl-piperazin-1-yl)-N-p-tolyl-butyramide 

Relevant articles and documents

Design, synthesis and computational studies of N-(substituted-phenyl)-4-(4-phenyl-1-piperazinyl)butanamides as potent anti-melanogenic and tyrosinase inhibitors

This manuscript describes the synthesis of some new N-(substituted-phenyl)-4-(4-phenyl-1-piperazinyl)butanamides (5a-c) through a facile bi-step strategy. The structures of these compounds were corroborated by their IR, EI-MS, 1H NMR, 13C NMR spectra along with CHN analysis data. The results of Mushroom tyrosinase in vitro inhibition revealed that all compounds were superb inhibitors of this enzyme and among them 5b was identified as the most active compound having IC50 value of 0.168 ± 0.057 μM, relative to the standard (16.841 ± 1.146 μM). The kinetic analysis (Ki = 0.22 μM) of this molecule revealed that it does not competitively inhibit the tyrosinase enzyme. It also significantly reduced (P 0.001) the enormous amount of pigments to about 75.373% in an in vivo protocol, when studied on the zebrafish embryos. Moreover, the cytotoxicity of these butanamides was also profiled and it was an inferred that of these molecules possess very mild cytotoxicity. So, it was consummated from the present investigation that these compounds might be utilized as less cytotoxic therapeutic agents for the betterment of skin related ailments.

A one pot protocol to convert nitro-arenes into: N-aryl amides

A two-step one pot, experimentally simple protocol, based on readily available and inexpensive reagents allowed the conversion of nitro-arenes directly to N-aryl amides. A metal-free reduction of the nitro group, mediated by trichlorosilane, followed by the addition of an anhydride afforded the corresponding N-aryl carboxyamide, that was isolated after a simple aqueous work up in good-excellent yields. When the methodology was applied to the reaction with γ-butyrolactone, the desired N-aryl butanamide derivative was obtained, featuring a chlorine atom at the γ-position, a functionalized handle that can be used for further synthetic manipulation of the reaction product. Such an intermediate has already been employed as a key advanced precursor of pharmaceutically active compounds.

Novel indole based hybrid oxadiazole scaffolds with: N -(substituted-phenyl)butanamides: Synthesis, lineweaver-burk plot evaluation and binding analysis of potent urease inhibitors

In the study presented herein, 4-(1H-indol-3-yl)butanoic acid (1) was sequentially transformed in the first phase into ethyl 4-(1H-indol-3-yl)butanoate (2), 4-(1H-indol-3-yl)butanohydrazide (3) and 5-[3-(1H-indol-3-yl)propyl]-1,3,4-oxadiazole-2-thiol (4)