191602-54-7

Basic information

• Product Name: 3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE
• Synonyms: 4-AMINO-2-BROMO(TRIFLUOROMETHOXY)BENZENE;3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE;3-Bromo-4-(trifluoromethoxy)aniline 98%;3-Bromo-4-(trifluoromethoxy)aniline98%;3-Fluoro-4-(Trifluoromethoxy)aniline;1-Amino-3-bromo-4-(trifluoromethoxy)benzene;3-broMo-4-(trifluoroMethoxy)benzenaMine
• CAS NO: 191602-54-7
• Molecular Formula: C7H5BrF3NO
• Molecular Weight: 256.02
• EINECS: 242-872-7
• Product Categories: Fluorine series
• Mol File: 191602-54-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 236.6 °C at 760 mmHg
• Flash Point: 96.9 °C
• Appearance: /
• Density: 1.726 g/cm³
• Refractive Index: 1.5100-1.5140
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.67±0.10(Predicted)
• CAS DataBase Reference: 3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE(191602-54-7)
• EPA Substance Registry System: 3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE(191602-54-7)

Safety Data

• Hazard Codes: T,Xi
• Statements: 36/37/38-43-25
• Safety Statements: 26-36/37/39-45-36/37
• RIDADR: UN2810
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 191602-54-7(Hazardous Substances Data)

Usage

General Description

3-Bromo-4-(trifluoromethoxy)aniline is a chemical compound known for its unique properties and application in various industries. It is a derivative of aniline with a bromine atom and a trifluoromethoxy group attached to the benzene ring. 3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE is commonly used in the synthesis of pharmaceuticals, agrochemicals, and dyes due to its ability to serve as a building block for organic synthesis. Additionally, it is also employed as an intermediate in the manufacturing of various specialty chemicals. The presence of the bromine and trifluoromethoxy groups imparts specific reactivity and solubility properties, making it a valuable component in the production of advanced materials and compounds. However, it is important to handle this chemical with caution, as it may pose health risks and environmental hazards if not properly managed.

InChI:InChI=1/F6P.NO2/c1-7(2,3,4,5)6;2-1-3/q-1;+1

Upstream product

• 200958-40-3 2-bromo-4-nitro-1-(trifluoromethoxy)benzene 
• 461-82-5 4-(trifluoromethoxy)aniline 

Downstream Products

• 1427026-60-5 C₂₉H₂₈F₃N₇O₂ 
• 1427026-54-7 C₂₀H₂₁BrF₃N₃O₂ 
• 1049730-98-4 3-bromo-N,N-dimethyl-4-(trifluoromethoxy)aniline 
• 866633-25-2 2-bromo-4-fluoro-1-(trifluoromethoxy)benzene 
• 866633-26-3 [2-(trifluoromethoxy)-5-fluorophenyl]boronic acid 
• 1076245-71-0 N-{6-amino-5-[5-fluoro-2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-1-methyl-1H-pyrazole-5-carboxamide 
• 1076245-69-6 N-{6-amino-5-[5-fluoro-2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-3-methylisoxazole-4-carboxamide 
• 839715-02-5 [3-(2-methyl-2H-pyrazol-3-yl)-4-trifluoromethoxyphenyl]carbamic acid tert-butyl ester 

Relevant articles and documents

Preparation method of 2, 4-dicarbonitrile trifluoromethoxybenzene

The invention discloses an industrial preparation method of 2, 4-dicarbonitrile trifluoromethoxybenzene. According to the industrial preparation method of the 2, 4-dicarbonitrile trifluoromethoxybenzene, p-aminotrifluoromethoxybenzene serves as an initial

Highly selective transfer hydrogenation of functionalised nitroarenes using cobalt-based nanocatalysts

Anilines are important feedstock for the synthesis of a variety of chemicals such as dyes, pigments, pharmaceuticals and agrochemicals. The chemoselective catalytic reduction of nitro compounds represents the most important and prevalent process for the manufacture of functionalized anilines. Consequently, the development of selective catalysts for the reduction of nitro compounds in the presence of other reducible groups is a major challenge and is crucial. In this regard, herein we show that the cobalt oxide (Co3O4-NGr@C) based nano-materials, prepared by the pyrolysis of cobalt-phenanthroline complexes on carbon constitute highly selective catalysts for the transfer hydrogenation of nitroarenes to anilines using formic acid as a hydrogen source. Applying these catalysts, a series of structurally diverse and functionalized nitroarenes have been reduced to anilines with unprecedented chemo-selectivity tolerating halides, olefins, aldehyde, ketone, ester, amide and nitrile functionalities.

Nanoscale Fe2O3-based catalysts for selective hydrogenation of nitroarenes to anilines

Production of anilines - key intermediates for the fine chemical, agrochemical, and pharmaceutical industries - relies on precious metal catalysts that selectively hydrogenate aryl nitro groups in the presence of other easily reducible functionalities. Herein, we report convenient and stable iron oxide (Fe2O3) - based catalysts as a more earth-abundant alternative for this transformation. Pyrolysis of iron-phenanthroline complexes on carbon furnishes a unique structure in which the active Fe2O 3 particles are surrounded by a nitrogen-doped carbon layer. Highly selective hydrogenation of numerous structurally diverse nitroarenes (more than 80 examples) proceeded in good to excellent yield under industrially viable conditions.