19178-25-7

Basic information

• Product Name: Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI)
• Synonyms: Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI);3,4-Dihydropyrido[3,4-d]pyrimidin-4-one;Pyrido[3.4-d]pyrimidin-4-ol;Pyrido[3,4-d]pyriMidin-4(3H)-one;3H-Pyrido[3,4-d]pyrimidin-4-one;3H,4H-Pyrido[3,4-d]pyrimidin-4-one;Pyrido[3,4-d]pyriMidin-4-one;Pyrido[3,4-d]pyrimidin-4(3H)
• CAS NO: 19178-25-7
• Molecular Formula: C₇H₅N₃O
• Molecular Weight: 147.1341
• Product Categories: PYRIMIDINE
• Mol File: 19178-25-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 305℃
• Boiling Point: 346.2oC at 760 mmHg
• Flash Point: 163.2oC
• Appearance: /
• Density: 1.47g/cm3
• Vapor Pressure: 5.85E-05mmHg at 25°C
• Refractive Index: 1.73
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.95±0.20(Predicted)
• CAS DataBase Reference: Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI)(19178-25-7)
• EPA Substance Registry System: Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI)(19178-25-7)

Safety Data

• Hazardous Substances Data: 19178-25-7(Hazardous Substances Data)

Usage

General Description

Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) is a chemical compound with a molecular formula of C8H5N3O. It is a heterocyclic compound containing a pyrido[3,4-d]pyrimidine ring system. Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) has potential pharmacological properties and has been studied for its potential use in medicinal chemistry. It is also used as a building block in the synthesis of various bioactive molecules. Pyrido[3,4-d]pyrimidin-4(3H)-one (8CI,9CI) has attracted interest in the field of drug discovery and development due to its unique structure and potential therapeutic applications.

InChI:InChI=1/C7H5N3O/c11-7-5-1-2-8-3-6(5)9-4-10-7/h1-4H,(H,9,10,11)

Upstream product

• 77287-34-4 formamide 
• 7579-20-6 3-Aminopyridine-4-carboxylic acid 
• 64188-97-2 3-aminopyridine-4-carboxamide 
• 122-51-0 orthoformic acid triethyl ester 
• 3473-63-0 formamidine acetic acid 

Downstream Products

• 51752-67-1 4-chloro-pyrido[3,4-d]pyrimidine 
• 1167545-68-7 4-[(8-methyl-2-phenylquinolin-3-yl)methoxy]pyrido[3,4-d]pyrimidine 

Relevant articles and documents

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives

Following the discovery of cell penetrant pyridine-4-carboxylate inhibitors of the KDM4 (JMJD2) and KDM5 (JARID1) families of histone lysine demethylases (e.g., 1), further optimization led to the identification of non-carboxylate inhibitors derived from pyrido[3,4-d]pyrimidin-4(3H)-one. A number of exemplars such as compound 41 possess interesting activity profiles in KDM4C and KDM5C biochemical and target-specific, cellular mechanistic assays.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

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