19178-37-1

Basic information

• Product Name: 2-amino-5-chloro-N-methylbenzamide(SALTDATA: FREE)
• Synonyms: 2-amino-5-chloro-N-methylbenzamide(SALTDATA: FREE)
• CAS NO: 19178-37-1
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.62286
• Mol File: 19178-37-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 334.9°Cat760mmHg
• Flash Point: 156.4°C
• Appearance: /
• Density: 1.281g/cm³
• Vapor Pressure: 0.000124mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 2-amino-5-chloro-N-methylbenzamide(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-chloro-N-methylbenzamide(SALTDATA: FREE)(19178-37-1)
• EPA Substance Registry System: 2-amino-5-chloro-N-methylbenzamide(SALTDATA: FREE)(19178-37-1)

Safety Data

• Hazardous Substances Data: 19178-37-1(Hazardous Substances Data)

Usage

Properties

1. Molecular formula: C8H8ClN2O
2. Commonly used as a reagent in organic synthesis and pharmaceutical research
3. Acts as an inhibitor of the enzyme monoamine oxidase A
4. Studied for its potential medicinal properties
5. Modulates serotonin levels in the central nervous system

Specific content

2-amino-5-chloro-N-methylbenzamide is a chemical compound with the molecular formula C8H8ClN2O
It is commonly used as a reagent in organic synthesis and pharmaceutical research
Acts as an inhibitor of the enzyme monoamine oxidase A, crucial in neurotransmitter metabolism in the brain
Studied for its potential medicinal properties, particularly its ability to modulate serotonin levels in the central nervous system
Widely used in drug discovery and development in the pharmaceutical industry

InChI:InChI=1/C8H9ClN2O/c1-11-8(12)6-4-5(9)2-3-7(6)10/h2-4H,10H2,1H3,(H,11,12)

Upstream product

• 4743-17-3 5-Chloroisatoic anhydride 
• 74-89-5 methylamine 
• 635-21-2 5-chloroanthranilic acid 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 748806-37-3 4-chloro-2-(methylaminomethyl)aniline 
• 1201934-87-3 5-chloro-2-[[2-[(1,3-dimethylpyrazol-4-yl)amino]-5-(trifluoromethyl)-4-pyridyl]amino]-N-methyl-benzamide 

Relevant articles and documents

Synthesis of 2-aryl quinazolinones: Via iron-catalyzed cross-dehydrogenative coupling (CDC) between N-H and C-H bonds

Herein, we describe the direct synthesis of quinazolinones via cross-dehydrogenative coupling between methyl arenes and anthranilamides. The C-H functionalization of the benzylic sp3 carbon is achieved by di-t-butyl peroxide under air, and the subsequent amination-aerobic oxidation process completes the annulation process. Iron catalyzed the whole reaction process and various kinds of functional groups were tolerated under the reaction conditions, providing 31 examples of 2-aryl quinazolinones using methyl arene derivatives in yields of 57-95percent. The synthetic potential has been demonstrated by the additional synthesis of aryl-containing heterocycles. This journal is

Two-directional approach for the rapid synthesis of 2,4-bis-aminoaryl pyridine derivatives

We have developed two different approaches in parallel to rapidly access 2,4-bis aminoaryl pyridine compounds from a common starting material. The C-4/C-2 approach uses palladium-mediated coupling reactions to sequentially functionalize C-4 and then C-2. An alternative C-2/C-4 route uses a regioselective SNAr reaction to first substitute at C-2 then subsequently at C-4 by a palladium-mediated reaction. Both approaches have been used successfully to provide a range of 2,4-bis-aminoaryl pyridine compounds.

TRIAZOLE COMPOUNDS USEFUL IN THERAPY

A compound of formula (I), or a pharmaceutically acceptable derivative thereof, wherein V represents -(CH2)d(O)e-, -CO-, or -CH(C1-6 alkyl)-; W is -0-, -S(O)a , or -N(R1')-R1 rep