191848-12-1

Basic information

• Product Name: 2,2-Difluoro-3-hydroxy-5-(4-isopropyl-phenyl)-4-methyl-pentanoic acid ethyl ester
• Synonyms: 2,2-Difluoro-3-hydroxy-5-(4-isopropyl-phenyl)-4-methyl-pentanoic acid ethyl ester
• CAS NO: 191848-12-1
• Molecular Weight: 314.373
• Mol File: 191848-12-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2-Difluoro-3-hydroxy-5-(4-isopropyl-phenyl)-4-methyl-pentanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Difluoro-3-hydroxy-5-(4-isopropyl-phenyl)-4-methyl-pentanoic acid ethyl ester(191848-12-1)
• EPA Substance Registry System: 2,2-Difluoro-3-hydroxy-5-(4-isopropyl-phenyl)-4-methyl-pentanoic acid ethyl ester(191848-12-1)

Safety Data

• Hazardous Substances Data: 191848-12-1(Hazardous Substances Data)

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 103-95-7 cyclamenaldehyde 

Relevant articles and documents

A convenient method for the preparation of α,α-difluoro-β-ketoesters and α,α-difluoroamides from terpenic and perfumery aldehydes

Reformatsky reactions with ethyl bromodifluoroacetate gave α,α-difluoro-β-hydroxyesters in good yield from the corresponding terpenic and perfumery aldehydes. α,α-Difluoro-β-ketoesters were prepared by Swern oxidation of the α,α-difluoro-β-hydroxyesters. The reaction of hydroxyesters with amines in the presence of lipase MY, lipase PS or Novozym 435 gave α,α-difluoroamides.