191930-58-2

Basic information

• Product Name: FLUTAX 1
• Synonyms: 7-O-[N-(4Fluoresceincarbonyl)-L-alanyl]Taxol;(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylamino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-4-ylesterN-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]-L-alanine;(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-9-[(2R,3S)-3-(benzoylaMino)-2-hydroxy-1-oxo-3-phenylpropoxy]-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[
• CAS NO: 191930-58-2
• Molecular Formula: C71H66N2O21
• Molecular Weight: 1283.28454
• Product Categories: Fluorescent Labels & Indicators;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 191930-58-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Refractive Index: 1.69
• Storage Temp.: Store at -20°C
• CAS DataBase Reference: FLUTAX 1(CAS DataBase Reference)
• NIST Chemistry Reference: FLUTAX 1(191930-58-2)
• EPA Substance Registry System: FLUTAX 1(191930-58-2)

Safety Data

• Hazardous Substances Data: 191930-58-2(Hazardous Substances Data)

Usage

Description

FLUTAX 1 is a fluorescent taxol derivative that exhibits high affinity for the taxol microtubule binding site (Ka ~ 10^7 M^-1). It is characterized by its orange solid appearance and is particularly useful for the direct imaging of the microtubule cytoskeleton, with an excitation maximum at approximately 495 nm and an emission maximum at approximately 520 nm.

Uses

Used in Cellular Biology and Microscopy:
FLUTAX 1 is used as a fluorescent probe for the direct imaging of the microtubule cytoskeleton in cellular biology and microscopy applications. Its high affinity for the taxol microtubule binding site allows for precise visualization and analysis of microtubule structures within cells.
Used in Drug Development and Screening:
FLUTAX 1 can be employed as a tool in drug development and screening processes, particularly for compounds targeting the microtubule cytoskeleton. Its fluorescent properties enable the assessment of drug interactions with microtubules and the evaluation of potential therapeutic effects.
Used in Research and Diagnostics:
In research and diagnostics, FLUTAX 1 serves as a valuable tool for studying the role of microtubules in various cellular processes and diseases. Its ability to bind with high affinity to the taxol microtubule binding site makes it a useful marker for investigating microtubule dynamics and related cellular functions.

Biological Activity

A fluorescent taxol derivative that binds to the taxol microtubule binding site with high affinity (K a ~ 10 7 M -1 ). Useful for direct imaging of the microtubule cytoskeleton. Excitation maximum ~ 495 nm; emission maximum ~ 520 nm.

InChI:InChI=1/C71H66N2O21/c1-35-51(91-67(86)57(78)56(39-17-11-8-12-18-39)73-62(80)40-19-13-9-14-20-40)33-71(87)61(93-66(85)41-21-15-10-16-22-41)59-69(7,60(79)58(89-37(3)74)55(35)68(71,5)6)52(32-53-70(59,34-88-53)94-38(4)75)92-65(84)36(2)72-63(81)42-23-26-45(48(29-42)64(82)83)54-46-27-24-43(76)30-49(46)90-50-31-44(77)25-28-47(50)54/h8-31,36,51-53,56-59,61,76,78,87H,32-34H2,1-7H3,(H,72,81)(H,73,80)(H,82,83)/t36-,51-,52-,53+,56-,57+,58+,59?,61-,69+,70-,71+/m0/s1