19255-60-8

Basic information

• Product Name: 2-Butenoic acid, 4,4-dimethoxy-, ethyl ester
• Synonyms: 4,4-dimethoxy-but-2-enoic acid ethyl ester;ethyl (E)-4,4-dimethoxy-but-2-enoate;Ethyl (E)-4,4-dimethoxy-2-butenoate
• CAS NO: 19255-60-8
• Molecular Formula: C8H14O4
• Molecular Weight: 174.197
• Mol File: 19255-60-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 4,4-dimethoxy-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 4,4-dimethoxy-, ethyl ester(19255-60-8)
• EPA Substance Registry System: 2-Butenoic acid, 4,4-dimethoxy-, ethyl ester(19255-60-8)

Safety Data

• Hazardous Substances Data: 19255-60-8(Hazardous Substances Data)

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 51673-84-8 dimethoxyacetaldehyde 
• 64-17-5 ethanol 
• 18778-96-6 (2E)-4,4-dimethoxybut-2-enal 

Downstream Products

• 603311-76-8 ethyl 2-(6-bromoimidazo[1,2-a]pyridin-3-yl)-acetate 
• 101820-69-3 imidazo[1,2-α]pyridin-3-yl-acetic acid ethyl ester 
• 1150567-97-7 (6-phenethyl-imidazo[1,2-b]pyridazin-3-yl)-acetic acid 
• 7328-34-9 ethyl 2E,4E-decadienoate 
• 3025-30-7 ethyl (2E,4Z)-2,4-decadienoate 
• 808141-23-3 1-benzyl-3-(3,4-dimethoxybenzyl)-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-20-0 4-[1-benzyl-4-dimethoxymethyl-2-oxo-3-(toluene-4-sulfonyl)piperidin-3-ylmethyl]benzoic acid methyl ester 
• 808141-13-1 1-benzyl-4-dimethoxymethyl-3-(4-methylbenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-15-3 1-benzyl-3-(2-bromobenzyl)-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-16-4 1-benzyl-3-(4-bromobenzyl)-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 
• 808141-17-5 1-benzyl-4-dimethoxymethyl-3-thiophen-2-ylmethyl-3-(toluene-4-sulfonyl)-piperidin-2-one 
• 808141-08-4 1-benzyl-4-dimethoxymethyl-3-(2-methylallyl)-3-(toluene-4-sulfonyl)piperidin-2-one 
• 640722-73-2 1-benzyl-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one 
• 2960-66-9 4-oxo-but-2-enoic acid ethyl ester 

Relevant articles and documents

Organocatalyzed Michael-Henry reactions: Enantioselective synthesis of cyclopentanecarbaldehydes via the dienamine organocatalysis of a succinaldehyde surrogate

Asymmetric formal [3+2] cycloadditions of 4-hydroxybut-2-enal, a succinaldehyde surrogate, and nitroalkenes with an organocatalyst provided cyclopentanecarbaldehydes containing four consecutive stereogenic centers with excellent enantioselectivities.

IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS

There is provided compounds of formula (I): wherein Z, M, R1, X, R3, R4 and R5 have meanings given in the description, an pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protei kinase (e.g. a PIM family kinase or PI3-K) is desired and/or required, an particularly in the treatment of cancer.

SYNTHESE STEREOSELECTIVE DU DECADIENE-2(E), 4(Z)OATE D'ETHYLE. A PARTIR D'UN MONOACETAL DU GLYOXAL

The glyoxal monoacetal 2, now readily available in bulk quantity, is a very useful synthon for the dienes-1,3 synthesis, as illustrated in the stereoselective preparation of ethyl 2E,4Z-decadienoate using two Wittig-type olefination reactions.