192725-97-6

Basic information

• Product Name: Carbamic acid, [(1R,3S,4S)-4-amino-3-hydroxy-1-(1-methylethyl)-5-phenylpentyl]-, 1,1-dimethylethyl ester
• CAS NO: 192725-97-6
• Molecular Formula: C19H32N2O3
• Molecular Weight: 336.475
• Mol File: 192725-97-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1R,3S,4S)-4-amino-3-hydroxy-1-(1-methylethyl)-5-phenylpentyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R,3S,4S)-4-amino-3-hydroxy-1-(1-methylethyl)-5-phenylpentyl]-, 1,1-dimethylethyl ester(192725-97-6)
• EPA Substance Registry System: Carbamic acid, [(1R,3S,4S)-4-amino-3-hydroxy-1-(1-methylethyl)-5-phenylpentyl]-, 1,1-dimethylethyl ester(192725-97-6)

Safety Data

• Hazardous Substances Data: 192725-97-6(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 156732-12-6 (4S)-4-(N,N-dibenzylamino)-3-oxo-5-phenyl-pentanonitrile 
• 111138-83-1 N,N-dibenzyl-L-phenylalanine benzyl ester 
• 497107-47-8 (2S,3S,5R)-5-Amino-2-dibenzylamino-6-methyl-1-phenyl-heptan-3-ol 

Downstream Products

• 192725-98-7 (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-(t-butyloxycarbonylamino)-1-phenyl-6-methylheptane 
• 192725-99-8 (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-amino-1-phenyl-6-methylheptane 

Relevant articles and documents

Novel Lopinavir analogues incorporating non-Aromatic P-1 side chains - Synthesis and structure-activity relationships

The HIV protease inhibitor Lopinavir has a pseudosymmetric core unit incorporating benzyl groups at both P-1, P-1′ positions. A series of analogues incorporating non-aromatic side chains at the P-1 position were synthesized and the structure-activity relationships explored.