192927-33-6

Basic information

• Product Name: 4-cyano-2-ethyl-2-(4-nitrophenyl)butanoic acid
• Synonyms: 4-cyano-2-ethyl-2-(4-nitrophenyl)butanoic acid
• CAS NO: 192927-33-6
• Molecular Weight: 262.265
• Mol File: 192927-33-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-cyano-2-ethyl-2-(4-nitrophenyl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-cyano-2-ethyl-2-(4-nitrophenyl)butanoic acid(192927-33-6)
• EPA Substance Registry System: 4-cyano-2-ethyl-2-(4-nitrophenyl)butanoic acid(192927-33-6)

Safety Data

• Hazardous Substances Data: 192927-33-6(Hazardous Substances Data)

Upstream product

• 24646-25-1 methyl 2-(4-nitrophenyl)butanoate 
• 7463-53-8 2RS-(4-nitrophenyl)butanoic acid 
• 192927-32-5 methyl 4-cyano-2-ethyl-2-(4-nitrophenyl)butanoate 

Relevant articles and documents

Resolution of 4-Cyano-4-(4-nitrophenyl)hexanoic acid: Synthesis of (R) and (S)-3-(4-aminophenyl)-3-ethylpiperidine- (aminoglutethimide)

Using (R)- or (S)-1-phenylethylamine as a resolving agent, (R)- and (S)-4-cyano-4-(4-nitrophenyl)hexanoic acids have been isolated. Cyclization of each enantiomer, followed by reduction of the nitro group, afforded (R)- and (S)-aminoglutethimide of high (>99% ee enantiomeric purity, respectively. The absolute configuration of (R)-(+)-3-(4-nitrophenyl)-3-ethylpiperidine-2,6-dione was solved by X-ray single crystal analysis thus establishing the (R)-configuration of the dextrorotatory aminoglutethimide. Attempted resolution of the other precursor of aminoglutethimide, 4-cyano-2-ethyl-(4-nitrophenyl)butanoic acid with (S)-1-phenylethylamine led to the formation of the double salt. Its crystal structure was elucidated by X-ray crystallographic analysis.