193469-44-2

Basic information

• Product Name: 2-BENZYL-PIPERIDIN-4-ONE
• Synonyms: 2-BENZYL-PIPERIDIN-4-ONE;2-Benzyl-4-piperidinone HCl;4-Piperidinone,2-(phenylmethyl)-
• CAS NO: 193469-44-2
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.25
• Mol File: 193469-44-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BENZYL-PIPERIDIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-PIPERIDIN-4-ONE(193469-44-2)
• EPA Substance Registry System: 2-BENZYL-PIPERIDIN-4-ONE(193469-44-2)

Safety Data

• Hazardous Substances Data: 193469-44-2(Hazardous Substances Data)

Usage

General Description

2-BENZYL-PIPERIDIN-4-ONE is a chemical compound that belongs to the class of piperidinones and contains a benzyl group attached to a piperidine ring. It is a white to off-white crystalline powder and is primarily used as an intermediate in the production of various pharmaceuticals and agrochemicals. 2-BENZYL-PIPERIDIN-4-ONE has also been investigated for its potential as a central nervous system agent, as well as for its insecticidal and herbicidal activities. Additionally, it has been studied for its potential anti-inflammatory and analgesic properties. However, further research is needed to fully understand its potential applications and effects.

Upstream product

• 193201-63-7 (±)-7-(phenylmethyl)-1,4-dioxa-8-azaspiro[4.5]decane 

Downstream Products

• 190964-86-4 (+/-)-1-[3,5-bis-(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone 
• 193480-28-3 (+/-)-1,1-dimethylethyl 4-oxo-2-(phenylmethyl)-1-piperidinecarboxylate 
• 190964-85-3 (+/-)-1-((3,5)-dimethylbenzoyl)-2-(phenylmethyl)-4-piperidinone 

Relevant articles and documents

1-(1,2-disubstituted pipeidinyl)-4-substituted piperidine derivatives

The present invention concerns compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein n is 0, 1 or 2; m is 1 or 2, provided that if m is 2, then n is 1; p is 0, 1 or 2; ═Q is ═O or ═NR3; X is a covalent bond or a bivalent radical of formula —O—, —S—, —NR3—; R1is Ar1; Ar1C1-6alkyl or di(Ar1)C1-6alkyl, wherein each C1-6alkyl group is optionally substituted with hydroxy, C1-4alkyloxy, oxo or a ketalized oxo substituent of formula —O—CH2—CH2—O— or —O—CH2—CH2—CH2—O—; R2is Ar2; Ar2C1-6alkyl; Het or HetC1-6alkyl; R3is hydrogen or C1-6alkyl; R4is hydrogen; C1-4alkyl; C1-4alkyloxyC1-4alkyl; hydroxyC1-4alkyl; carboxyl; C1-4alkyloxycarbonyl or Ar3; R5is hydrogen; hydroxy; Ar3; Ar3C1-6alkyloxy; di(Ar3)C1-6alkyloxy; Ar3C1-6alkylthio; di(Ar3)C1-6alkylthio; Ar3C1-6alkylsulfoxy; di(Ar3)C1-6alkylsulfoxy; Ar3C1-6alkylsulfonyl; di(Ar3)C1-6alkylsulfonyl; —NR7R8; C1-6alkyl substituted with —NR7R8; or a radical of formula (a-1) or (a-2); R4and R5may also be taken together; R6is hydroxy; C1-6alkyloxy; C1-6alkyl or Ar3C1-6alkyl; Ar1, Ar2and Ar3are phenyl or substituted phenyl; Ar2is also naphtalenyl; and Het is an optionally substituted monocyclic or bicyclic heterocycle; as substance P antagonists; their preparation, compositions containing them and their use as a medicine.

1-(1,2-Disubstituted piperidinyl)-4-substituted piperidine derivatives

The present invention concerns compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein n is 0, 1 or 2; m is 1 or 2, provided that if m is 2, then n is 1; p is 0, 1 or 2; =