1937-19-5

Basic information

• Product Name: AMINOGUANIDINE HYDROCHLORIDE
• Synonyms: amino-guanidinhydrochloride;hydrazinecarboximidamidehydrochloride;carbazamidine monohydrochloride;AMINOGUANIDINE HYDROCHLORIDE, 98+%;Aminoguanidine HCL;AMINOGUANIDINE SALT;GUANYLHYDRAZINEHCL;GUANIDINE,AMINO-,MONOHYDROCHLORIDE
• CAS NO: 1937-19-5
• Molecular Formula: CH₇N₄*Cl
• Molecular Weight: 110.54608
• EINECS: 217-707-7
• Product Categories: Pharmaceutical Intermediates;Nitric Oxide;Signalling;TUSACAPINE
• Mol File: 1937-19-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 162-166 °C(lit.)
• Boiling Point: 261.4 °C at 760 mmHg
• Flash Point: 111.9 °C
• Appearance: White to off-white/Crystals
• Density: g/cm³
• Vapor Pressure: 0.0116mmHg at 25°C
• Storage Temp.: Store at RT
• Solubility: Completely soluble in water
• Water Solubility: 506.7g/L at 20℃
• Merck: 13,440
• BRN: 3909606
• CAS DataBase Reference: AMINOGUANIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: AMINOGUANIDINE HYDROCHLORIDE(1937-19-5)
• EPA Substance Registry System: AMINOGUANIDINE HYDROCHLORIDE(1937-19-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: ME8430000
• F: 10-21
• Hazardous Substances Data: 1937-19-5(Hazardous Substances Data)

Usage

Description

Aminoguanidine hydrochloride is a white to off-white crystalline compound that has been identified as an inhibitor of animal nitric oxide (NO)-synthase. Its crystal structure, investigated through Fourier and least squares methods, reveals a monoclinic form with a planar guanidine part of the aminoguanidinium ion. Aminoguanidine is known to be equipotent to L-NMMA and L-NNA as an inhibitor of iNOS, with IC50 values of 5.4 and 160 μM for mouse iNOS and rat nNOS, respectively. It also inhibits the induction of iNOS protein expression by endotoxin in rat macrophages.

Uses

Used in Pharmaceutical Industry:
Aminoguanidine hydrochloride is used as an inhibitor of nitric oxide synthase (NOS) for the potential treatment of heart failure. It is also utilized in the synthetic preparation of highly selective and potent G-protein-coupled receptor kinase 2 (GRK2) inhibitors.
Used in Antitussive Applications:
Aminoguanidine hydrochloride serves as an antitussive agent, helping to suppress or reduce coughing.
Used in Enzyme Inhibition:
As an α-Glucosidase inhibitor, the hydroxyethyl derivative of 1-deoxynojirimycin, aminoguanidine hydrochloride plays a role in managing diabetes by slowing down the breakdown of carbohydrates in the body.
Used in Dental Applications:
Aminoguanidine hydrochloride may be employed as a nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature-induced periodontitis in rats.
Used in Antibacterial Applications:
Aminoguanidine hydrochloride may be used in the synthesis of 5-guanylhydrazone derivatives, which exhibit antibacterial activity against both Escherichia coli and Staphylococcus aureus, contributing to the development of new antimicrobial agents.

Flammability and Explosibility

Notclassified

Biochem/physiol Actions

Inhibits both constitutive and inducible nitric oxide synthetase.

InChI:InChI=1/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H

Upstream product

• 64-17-5 ethanol 
• 420-04-2 CYANAMID 
• 2582-30-1 aminoguanidine bicarbonate 
• 1309884-92-1 acetic acid 2-guanylhydrazide hydrochloride 

Downstream Products

• 4427-16-1 isonicotinic acid 2-amidinohydrazide 
• 22819-11-0 bis(5-amino-1,2,4-triazol-3-yl)methane 
• 76584-58-2 phenacylidenamino-guanidine 
• 23484-24-4 4,4'-oxy-di-benzaldehyde bis-carbamimidoylhydrazone 
• 942-72-3 3-amino-6-phenyl-1,2,4-triazine 
• 113950-41-7 4,4'-propanediyldioxy-di-benzaldehyde bis-carbamimidoylhydrazone 
• 114931-96-3 3,3'-pentanediyldioxy-di-benzaldehyde bis-carbamimidoylhydrazone 
• 110939-08-7 4,4'-(3-oxa-pentanediyldioxy)-di-benzaldehyde bis-carbamimidoylhydrazone 
• 22819-10-9 1H,1′H-[3,3′-bi-1,2,4-triazole]-5,5′-diamine 
• 4364-74-3 2-cyclohexylidene-1-hydrazinecarboximidamide 
• 54655-98-0 3-methyl-5-oxo-2,5-dihydro-1H-pyrazole-1-carboximidamide 
• 38407-85-1 (4-dimethylamino-benzylidenamino)-guanidine 
• 93312-45-9 N,N'-bis-benzylidenamino-N-methyl-guanidine 
• 1003-35-6 3-Amino-1,2,4-triazol-5-on 

Relevant articles and documents

Green Energetic Nitrogen-Rich Salts of 1,1′-Dinitramino-5,5′-bistetrazolate

A series of nitrogen-rich energetic salts of 1,1′-dinitramino-5,5′-bistetrazolate (DNABT) guanidinium (1), aminoguanidinium (2), diaminoguanidinium (3), triaminoguanidinium (4), diaminouronium (5), 3,4-diamino-1,2,4-triazolium (6), and ethylenediammonium (7) was synthesized by a metathesis strategy and characterized by elemental analysis, mass spectrometry, and IR spectroscopy as well as single-crystal X-ray diffraction and differential scanning calorimetry (DSC). The natural bond orbitals (NBOs) and electrostatic potentials (ESPs) were further computed for a better understanding of the structures of the DNABT molecule. The heats of formation were calculated based on the Born–Haber energy cycle. The detonation parameters were evaluated by using the EXPLO5 program, and the sensitivities were measured according to BAM standers. These new salts exhibit highly positive heats of formation (407.0–1377.9 kJ mol?1) and good thermal stabilities (180–211 °C). Most of these compounds possess detonation velocities comparable to RDX and acceptable detonation pressures. The high volumes of explosion gases of the salts 3 and 4 (921 and 933 L kg?1, respectively) further support their power as explosives. The enhancing performances, the fact of being free of metals, and the more moderate sensitivities than K2DNABT, suggest that the salts 4 (D=8851 m s?1, P=29.0 GPa), 5 (D=9053 m s?1, P=32.3 GPa), and 6 (D=8835 m s?1, P=30.2 GPa) might be potential environmentally friendly energetic materials.

PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS

The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

Thermodynamic and kinetic aspects of the reaction of aminoguanidine with malonic acid in acidic aqueous solutions

Thermodynamic and kinetic features of the reaction of aminoguanidine with malonic acid in aqueous solutions at pH 0.5-1.3 to give mono-and diguanylhydrazides of malonic acid were examined, and the reaction mechanism was suggested.