193954-27-7 Usage
Description
Fmoc-L-beta-homoisoleucine, also known as N-(9-fluorenylmethoxycarbonyl)-L-beta-homoisoleucine, is a synthetic amino acid derivative that is widely used in various applications due to its unique chemical properties. It is a white powder and may contain approximately 8% (w/w) ethyl acetate.
Uses
Used in Pharmaceutical Industry:
Fmoc-L-beta-homoisoleucine is used as a building block for the synthesis of peptides and peptidomimetics. Its application is crucial in the development of new drugs and therapeutic agents, particularly in the areas of oncology, immunology, and neurobiology.
Used in Chemical Research:
In the field of chemical research, Fmoc-L-beta-homoisoleucine serves as an essential component in the study of protein structure, function, and interactions. It is also utilized in the development of novel chemical methodologies and techniques for peptide synthesis.
Used in Biochemical Applications:
Fmoc-L-beta-homoisoleucine is employed as a reagent in the synthesis of bioactive peptides and proteins, which are vital for understanding biological processes and developing targeted therapies for various diseases.
Used in Material Science:
In material science, Fmoc-L-beta-homoisoleucine can be used to develop novel biomaterials and surfaces with specific properties, such as enhanced biocompatibility, controlled drug release, or improved cell adhesion and growth.
Check Digit Verification of cas no
The CAS Registry Mumber 193954-27-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,3,9,5 and 4 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 193954-27:
(8*1)+(7*9)+(6*3)+(5*9)+(4*5)+(3*4)+(2*2)+(1*7)=177
177 % 10 = 7
So 193954-27-7 is a valid CAS Registry Number.
InChI:InChI=1/C22H25NO4/c1-3-14(2)20(12-21(24)25)23-22(26)27-13-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,14,19-20H,3,12-13H2,1-2H3,(H,23,26)(H,24,25)/t14-,20+/m0/s1
193954-27-7Relevant articles and documents
Homologation of α-amino acids to β-amino acids: 9-Fluorenylmethyl chloroformate as a carboxyl group activating agent for the synthesis of Nα-protected aminoacyldiazomethanes
Kantharaju,Suresh Babu, Vommina V.
, p. 2152 - 2158 (2007/10/03)
An efficient and stereospecific homologation of urethane-protected α-amino acids to β-amino acids by Arndt-Eistert approach using an equimolar mixture of Fmoc-/Boc-/Z-α-amino acid and 9-fluorenylmethyl chloroformate for the acylation of diazomethane synth
Synthesis of Fmoc-β-homoamino acids by ultrasound-promoted wolff rearrangement
Müller, Annett,Vogt, Carla,Sewald, Norbert
, p. 837 - 841 (2007/10/03)
A highly efficient protocol for Amdt-Eistert chain elongation of the base-labile fluorenylmethoxycarbonyl (Fmoc) protected α-amino acids by Ag+- catalyzed, ultrasound-promoted Wolff rearrangement of the corresponding α- diazo ketones at room temperature is described. The enantiomeric purity of the products was examined by capillary zone electrophoresis with chiral buffer systems.
