194044-54-7

Basic information

• Product Name: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonami de
• Synonyms: 4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide;Ccris 9330;Hsdb 7038;p-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide
• CAS NO: 194044-54-7
• Molecular Formula: C17H14F3N3O2S
• Molecular Weight: 0
• Mol File: 194044-54-7.mol
• Article Data: 125

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonami de(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonami de(194044-54-7)
• EPA Substance Registry System: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonami de(194044-54-7)

Safety Data

• Hazardous Substances Data: 194044-54-7(Hazardous Substances Data)

Upstream product

• 190711-56-9 4-[5-(4-methylphenyl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonyl chloride 
• 720-94-5 4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione 
• 17852-52-7 4-hydrazinobenzene-1-sulfonamide hydrochloride 
• 74-88-4 methyl iodide 
• 55949-65-0 4-[1-(4-methylphenyl)vinyl]morpholine 
• 929030-65-9 N-[bis(4-methoxyphenyl)phenylmethyl]-4-[3-(bromodifluoromethyl)-5-p-tolylpyrazol-1-yl]-benzenesulfonamide 
• 929030-63-7 4-bromo-4,4-difluoro-1-(p-tolyl)butane-1,3-dione 
• 929030-64-8 4-(3-(bromodifluoromethyl)-5-(p-tolyl)-1H-pyrazol-1-yl)benzenesulfonamide 
• 4392-54-5 4-aminosulfonylphenylhydrazine 
• 122-00-9 para-methylacetophenone 
• 190711-47-8 1-(4-Methanesulfinyl-phenyl)-5-p-tolyl-3-trifluoromethyl-1H-pyrazole 
• 190711-63-8 Acetic acid 4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-phenylsulfanylmethyl ester 
• 190711-64-9 Acetic acid 4-(5-p-tolyl-3-trifluoromethyl-pyrazol-1-yl)-benzenesulfonylmethyl ester 
• 284035-29-6 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide dimethylformamide monosolvate 

Downstream Products

• 1426535-47-8 C₂₆H₂₂F₃N₃O₃S 
• 1426535-45-6 C₂₆H₂₁F₃N₄O₅S 
• 1426535-43-4 C₂₅H₁₉F₃N₄O₅S 
• 1446354-68-2 N-[(4-trifluoromethylphenyl)carbamothioyl]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide 
• 1446354-69-3 N-(3-ethyl-4-oxo-1,3-thiazolidin-2-yldene)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide 
• 1446354-64-8 N-(ethylcarbamothioyl)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide 
• 1446354-65-9 N-(phenylcarbamothioyl)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide 
• 1446354-70-6 N-(3-phenyl-4-oxo-1,3-thiazolidin-2-yldene)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide 
• 1446354-66-0 N-(benzylcarbamothioyl)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide 
• 1446354-71-7 N-(3-benzyl-4-oxo-1,3-thiazolidin-2-yldene)-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide 
• 1446354-67-1 N-[(4-nitrophenyl)carbamothioyl]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide 
• 1446354-72-8 N-[3-(4-nitrophenyl)-4-oxo-1,3-thiazolidin-2-yldene]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1Hpyrazol-1-yl]benzenesulfonamide 
• 586412-28-4 (Z)-4-oxo-4-(4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenylsulfonamido)butanoic acid 
• 1448300-85-3 4-(dimethylamino)-N-((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)sulfonyl)butanamide 

Relevant articles and documents

Rapid Access to N-Protected Sulfonimidoyl Fluorides: Divergent Synthesis of Sulfonamides and Sulfonimidamides

Herein we report a practical and efficient copper-catalyzed approach for the conversion of various arenediazonium salts to the corresponding N-protected sulfonimidoyl fluorides. This operationally simple protocol tolerates a wide range of functional groups and can be applied to the late-stage modification of complex bioactive molecules. Furthermore, pharmaceutically important primary sulfonamides and sulfonimidamides derived from these valuable N-protected sulfonimidoyl fluoride units were prepared in minimal synthetic steps.

Nickel(II)-Catalyzed Addition of Aryl and Heteroaryl Boroxines to the Sulfinylamine Reagent TrNSO: The Catalytic Synthesis of Sulfinamides, Sulfonimidamides, and Primary Sulfonamides

We report a redox-neutral Ni(II)-catalyzed addition of (hetero)aryl boroxines to N-sulfinyltritylamine (TrNSO). The reactions use a catalyst generated from the combination of commercial, air-stable NiCl2·(glyme) and a commercially available bipyridine lig

Preparation method of high-purity celecoxib

The invention discloses a preparation method of high-purity celecoxib. According to the preparation method, a p-methylbenzoyl halide and trifluoroacetone are reacted under the action of an alkali to generate 4, 4, 4-trifluoro-1-(4-methylphenyl)-1, 3-butanedione, and then 4, 4, 4-trifluoro-1-(4-methylphenyl)-1, 3-butanedione is reacted with p-aminosulfonylphenylhydrazine/hydrochloride in an acidicaqueous solution to obtain high-purity celecoxib. According to the invention, the reaction time required for preparing celecoxib is greatly reduced, and the reaction period is only 20-30% of the original reaction period; reaction conditions are mild, and few isomer impurities are generated in the reaction; the output of three wastes is greatly reduced, and the generated wastewater is very easy totreat; and various impurities in the reaction can be effectively controlled without recrystallization.