19479-65-3 Usage
Description
Alpha-Ethoxyacrylonitrile, also known as 2-Ethoxy-2-propenenitrile, is an organic compound that serves as a valuable intermediate in the synthesis of various chemical compounds. It is characterized by its unique molecular structure, which includes a nitrile group and an ethoxy group, making it a versatile building block in the chemical industry.
Uses
Used in Pharmaceutical Industry:
Alpha-Ethoxyacrylonitrile is used as an intermediate in the synthesis of 2-Acetyl-4(5)-(1R,2S,3R,4-tetrahydroxybutyl)imidazole, a compound that has been shown to lower circulating lymphocytes count when fed to rats. This application is significant in the development of potential treatments for conditions involving abnormal lymphocyte levels.
Used in the Synthesis of Caramel Color III:
Alpha-Ethoxyacrylonitrile is utilized in the production of a minor constituent of Caramel Color III, which is an essential component in the food industry for providing a specific color and flavor to various products.
Used in the Treatment of Autoimmune Disorders:
The compound is also used as an intermediate in the synthesis of (R,S,R)-2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)-imidazole (A188490), a compound that inhibits sphingosine-1-phosphate (S1P) lyase. This inhibition is crucial in the treatment of autoimmune disorders, as it can help regulate the immune system and reduce inflammation.
Check Digit Verification of cas no
The CAS Registry Mumber 19479-65-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,4,7 and 9 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 19479-65:
(7*1)+(6*9)+(5*4)+(4*7)+(3*9)+(2*6)+(1*5)=153
153 % 10 = 3
So 19479-65-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H7NO/c1-3-7-5(2)4-6/h2-3H2,1H3
19479-65-3Relevant articles and documents
Practical synthesis of potent sphingosine-1-phosphate lyase inhibitors THI and LX2931
Zhang, Haiming,Yan, Jie,Bednarz, Mark S.,Hernandez, Gonzalo,Lu, Yuelie,Courtney, Lawrence F.,Chen, Jason,Hu, Weifeng,Liu, Renmao,Yang, Xiaogen,Wu, Wenxue
, p. 4041 - 4046 (2013)
A practical and scalable synthesis of in vivo sphingosine-1-phosphate lyase inhibitor LX2931 (1) is described. The synthetic route features an improved Büchi cyclocondensation of 2-ethoxyacrylonitrile (3) with either 1-amino-1-deoxy-d-fructose acetate (4a) or d-(+)-glucosamine hydrochloride (4b) to produce 1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone (2, THI), followed by oximation of THI and acid-promoted oxime isomerization to give LX2931 (1).
COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF INFECTIOUS DISEASES AND CANCER
-
Page/Page column 35; 39, (2021/02/26)
The invention provides the imidazole, oxazole and thiazole compounds and use thereof in methods for treating a disease or a disorder, such as infectious diseases and cancer, wherein inhibition of sphingosine-1-phosphate lyase is beneficial to treat the disease or the disorder.
