19513-91-8

Basic information

• Product Name: [3-(bromomethyl)-3-phenyloxiran-2-yl](phenyl)methanone
• Synonyms: methanone, [3-(bromomethyl)-3-phenyloxiranyl]phenyl-
• CAS NO: 19513-91-8
• Molecular Formula: C₁₆H₁₃BrO₂
• Molecular Weight: 317.1772
• Mol File: 19513-91-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 434.2°C at 760 mmHg
• Flash Point: 216.4°C
• Density: 1.453g/cm³
• Vapor Pressure: 9.63E-08mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: [3-(bromomethyl)-3-phenyloxiran-2-yl](phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(bromomethyl)-3-phenyloxiran-2-yl](phenyl)methanone(19513-91-8)
• EPA Substance Registry System: [3-(bromomethyl)-3-phenyloxiran-2-yl](phenyl)methanone(19513-91-8)

Safety Data

• Hazardous Substances Data: 19513-91-8(Hazardous Substances Data)

Usage

Description

[3-(bromomethyl)-3-phenyloxiran-2-yl](phenyl)methanone is a complex organic compound characterized by the presence of an oxiran-2-yl group, a phenyl group, and a bromomethyl group attached to an oxirane ring. [3-(bromomethyl)-3-phenyloxiran-2-yl](phenyl)methanone also features a methanone group, indicating the presence of a carbonyl group attached to a methyl group. The structure of this compound suggests potential reactivity similar to other epoxides and the possibility of being used as a building block in the synthesis of other compounds due to its diverse functional groups.

Uses

Used in Organic Synthesis:
[3-(bromomethyl)-3-phenyloxiran-2-yl](phenyl)methanone is used as a synthetic building block for the creation of various organic compounds. Its unique structure, which includes an oxirane ring, a phenyl group, and a bromomethyl group, allows for a range of reactions and the formation of diverse products in the field of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, [3-(bromomethyl)-3-phenyloxiran-2-yl](phenyl)methanone is used as an intermediate in the synthesis of pharmaceutical compounds. [3-(bromomethyl)-3-phenyloxiran-2-yl](phenyl)methanone's structural features, such as the aromatic phenyl group and the reactive oxirane ring, make it a valuable precursor for the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
[3-(bromomethyl)-3-phenyloxiran-2-yl](phenyl)methanone is also utilized in chemical research as a model compound to study the reactivity and properties of epoxides, aromatic rings, and other functional groups. This helps researchers gain a deeper understanding of the underlying chemical reactions and mechanisms, which can lead to the discovery of new synthetic pathways and applications for this compound and its derivatives.

Upstream product

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Downstream Products

• 101735-53-9 (2RS,3SR)-2-acetoxy-3,4-dibromo-1,3-diphenyl-butan-1-one 
• 3274-56-4 2,4-diphenylpyrrole 
• 101118-69-8 (2RS,3SR)-3,4-dibromo-2-hydroxy-1,3-diphenyl-butan-1-one 
• 93022-03-8 2-hydroxy-1,3-diphenyl-but-3-en-1-one 
• 495-71-6 phenacylacetophenone 
• 860759-20-2 1,2,4-triphenyl-pyrrol-3-ol 
• 857419-10-4 3-chloro-1,2,4-triphenyl-pyrrole 
• 7472-85-7 (2RS,3SR)-2-benzoyloxy-3,4-dibromo-1,3-diphenyl-butan-1-one 
• 101735-53-9 (2RS,3RS)-2-acetoxy-3,4-dibromo-1,3-diphenyl-butan-1-one 
• 91899-75-1 1,3-Diphenyl-1,2-butanedione 
• 113158-66-0 2-hydroxy-1,3-diphenyl-butan-1-one 
• 7472-84-6 2-acetoxy-1,3-diphenyl-but-3-en-1-one 
• 107924-53-8 2-acetyloxy-1,3-diphenyl-1-butanone 
• 1026-46-6 3,5-Diphenylpyridazine 

Relevant articles and documents

An efficient and odorless synthesis of thioethers using 2-[Bis(alkylthio)methylene]-3-oxo-N-o-tolylbutanamides as thiol equivalents

Using 2-[bis(alkylthio)methylene]-3-oxo-N-o-tolylbutanamides 1 as odorless thiol equivalents, an efficient and odorless synthesis of thioethers has been developed. Promoted by NaOH in EtOH, the cleavage of 1 commences to generate thiolate anions, and the generated thiolate anions then react with halides to give various thioethers in good yield. It is noteworthy that only a very faint odor of thiols can be perceived during both the reaction and the workup. Using 2-[bis(alkylthio)methylene]-3-oxo-N-o-tolylbutanamides as odorless thiol equivalents, an efficient and odorless synthesis of thioethers has been developed. Promoted by NaOH in EtOH, the cleavage of 2-[bis(alkylthio)methylene] -3-oxo-N-o-tolylbutanamides commences to generate thiolate anions, and the generated thiolate anions then react with halides to give various thioethers in good yield. Copyright

Regioselective reactions of phenacyl bromide with active methylene compounds

The reactivity of phenacyl bromide with active methylene compounds in the presence of alcoholic KOH, BTEAC (PTC), NaOEt and K2CO3 has been studied.

Reaction of α-halo organoindium reagents with carbonyl compounds and electron-deficient alkenes

A variety of α-halo organoindium reagents were prepared in situ from the reaction of gem-dihalo compounds with indium metal, and their reactions with carbonyl compounds and electron-deficient alkenes were examined. The reactions of simple 1,1-diiodoalkanes with indium metal gave no defined products but benzal iodide gave stilbene in a moderate yield. α-Halo organoindium reagents derived from α,α-dibromo carbonyl compounds gave oxiranes and cyclopropanes upon the reactions with aldehydes and alkenes, respectively. 3,3-Dichloropropenes reacted with aldehydes in the presence of indium metal to give the corresponding chlorohydrins and/or homoallylalcohols, depending on the structures of both the dichloropropenes and aldehydes employed.